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TranscriptomicsComparative expression profiles of human embryonic stem cells among different feeders and conditioned media
Background: The hES-T3 cell line with normal female karyotype was used to differentiate into autogeneic fibroblast-like cells (T3HDF) as feeder to support the undifferentiated growth of hES-T3 cells (T3/HDF) for 14 passages. A feeder-free culture on Matrigel in hES medium conditioned by these autoge...
ORGANISM(S): Homo sapiens 
2011-01-12 | E-GEOD-19902 | biostudies-arrayexpress
TranscriptomicsYWHAZ is an Invasion and Metastasis promoting genes of Lung cancer
Metastasis is a major cause leading to mortality for lung cancer patients. We identified YWHAZ as a potential metastasis-promoting candidate and found that overexpression of YWHAZ promotes lung cancer cell proliferation, anchorage-independent growth, migration, and invasion in vitro, as well as tumo...
ORGANISM(S): Homo sapiens 
2012-11-07 | E-GEOD-20318 | biostudies-arrayexpress
TranscriptomicsmicroRNA and mRNA expression profiles of human embryonic stem cells treated with activin A
Human embryonic stem (hES) cells have the capacities to propagate for extended periods and to differentiate into cell types from all three germ layers both in vitro and in vivo. These characteristics of self-renewal and pluripotency enable hES cells having the potential to provide an unlimited suppl...
ORGANISM(S): Homo sapiens 
2010-09-10 | E-GEOD-16910 | biostudies-arrayexpress
TranscriptomicsmicroRNA and mRNA expression profiles of human pancreatic islet-like cell clusters
Type 1 diabetes is an autoimmune destruction of pancreatic islet beta cell disease, and it is important to find new alternative source of the islet beta cells to replace the damaged cells. Human embryonic stem (hES) cells possess unlimited self-renewal and pluripotency and thus have the potential to...
ORGANISM(S): Homo sapiens 
2010-09-29 | E-GEOD-14503 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human embryonic stem cell differentiation
MicroRNAs (miRNAs) are noncoding RNAs of approximately 22 nucleotides in length that usually suppress the translation of target messenger RNAs (mRNAs) through partial complementarity to the 3¡¦ untranslated region (3¡¦ UTR) of protein-coding mRNAs in animals. However, there is increasing evidenc...
ORGANISM(S): Homo sapiens 
2008-11-13 | E-GEOD-9440 | biostudies-arrayexpress
TranscriptomicsJAG1 is an Invasion and Metastasis promoting genes of Lung cancer
Background: JAG-1 is a ligand of Notch signaling and can regulate cell differentiation and proliferation in cancers. Recent studies indicated that JAG1 is a gene associated with cancer progression. Therefore, we investigated the role of JAG1 in lung cancer progression. Methods: The expression of JAG...
ORGANISM(S): Homo sapiens 
2013-01-12 | E-GEOD-14995 | biostudies-arrayexpress
TranscriptomicsComparative profiling of mRNA expression in human mesenchymal stem cells derived from adult adipose and lipoma tissues
Human mesenchymal stem cells (MSCs) have been isolated from adult adipose tissues, and were shown to have ability to differentiate into multiple mesodermal lineages as well as non-mesodermal lineages. MSC had also been isolated from lipoma, and the lipoma-derived MSCs (LM6) showed very similar stem ...
ORGANISM(S): Homo sapiens 
2009-09-08 | E-GEOD-12843 | biostudies-arrayexpress
TranscriptomicsThe differentially expressed genes induced by EV71 infection
Virus infection may shut off host protein synthesis in order to achieve the replicative advantage over host cells. It is well known that human pathogenic viruses, particularly the picornaviruses, can block host protein synthesis by cleavage or inhibition of eukaryotic initiation factors (eIFs). In t...
ORGANISM(S): Homo sapiens 
2011-01-03 | E-GEOD-15323 | biostudies-arrayexpress
TranscriptomicsCancer-Associated Fibroblasts Support Lung Cancer Stemness through Paracrine IGF-II/IGF1R/Nanog Signaling
The CLS1/CAF co-culture maintained the cancer stemness. This cancer stemness was lost when the CAF feeder cells were removed during passaging. To investigate the specific signaling pathways and markers of lung CSCs, we analyzed the gene expression profile of the CLS1 sphere after CLS1/CAF co-cultur...
ORGANISM(S): Homo sapiens 
2014-03-25 | E-GEOD-38678 | biostudies-arrayexpress
UnknownLow-Density Lipoprotein Cholesterol and Mortality in Patients With Intracerebral Hemorrhage in Taiwan.
Not available
S-EPMC8802633 | biostudies-literature
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