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MetabolomicsL-fucose and fucoidan alleviate high-salt diet-promoted acute inflammation

Excessive salt intake is a widespread health issue observed in almost every country around the world. A high salt diet (HSD) has a strong correlation with numerous diseases, including hypertension, chronic kidney disease and autoimmune disorders. However, the mechanisms underlying HSD-promotion o...

2024-02-21 | MTBLS9134 | MetaboLights
MetabolomicsHuanglianjiedu Decoction ameliorates high-fat diet-induced lipid metabolism disorder
In this study, a HFD-induced lipid metabolism disorder model was established in C57BL/6 mice in vivo, and a palmitic acid (PA)-induced hepatocyte lipid accumulation model was constructed in HepG2 cells in vitro. Using component identification, network pharmacology, transcriptome sequencing, molecula...
2026-08-26 | MTBLS14701 | MetaboLights
MetabolomicsYinchenhao Decoction ameliorates high-fat diet-induced lipid metabolism disorder

In this study, a HFD-induced lipid metabolism disorder model was established in C57BL/6 mice in vivo, and a palmitic acid (PA)-induced hepatocyte lipid accumulation model was constructed in HepG2 cells in vitro. Using component identification, network pharmacology, transcriptome sequencing, molec...

2027-06-26 | MTBLS14689 | MetaboLights
MetabolomicsWlingsan ameliorates high-fat diet-induced lipid metabolism disorder

In this study, a HFD-induced lipid metabolism disorder model was established in C57BL/6 mice in vivo, and a palmitic acid (PA)-induced hepatocyte lipid accumulation model was constructed in HepG2 cells in vitro. Using component identification, network pharmacology, transcriptome sequencing, molec...

2026-08-26 | MTBLS14691 | MetaboLights
UnknownThe MALAT1 gene polymorphism and its relationship with the onset of congenital heart disease in Chinese.
Not available
S-EPMC6048208 | biostudies-literature
UnknownProtein phosphatase 4 promotes Hedgehog signaling through dephosphorylation of Suppressor of fused.
Not available
S-EPMC7442787 | biostudies-literature
UnknownAMPK attenuates SHH subgroup medulloblastoma growth and metastasis by inhibiting NF-κB activation.
Not available
S-EPMC9867863 | biostudies-literature
ProteomicsA proteomic classifier panel for early screening of colorectal cancer
Colorectal cancer (CRC) is a leading cause of cancer-related death. Diagnosis at an early stage can greatly improve the patient outcome. Therefore, developing sensitive and specific non-invasive screening and diagnostic methods has a tremendous potential to combat the disease.
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD042639 | Pride
Plasma proteome biomarker 
ProteomicsA proteomic classifier panel for early screening of colorectal cancer part II
Colorectal cancer (CRC) is a leading cause of cancer-related death. Diagnosis at an early stage can greatly improve the patient outcome. Therefore, developing sensitive and specific non-invasive screening and diagnostic methods has a tremendous potential to combat the disease.
ORGANISM(S): Homo sapiens (Human) 
2024-05-24 | PXD042652 | Pride
Plasma proteome biomarker 
TranscriptomicsA sumoylation-dependent transcriptional subprogram is required for Myc-driven tumorigenesis
Myc is an oncogenic transcription factor frequently dysregulated in human cancer. To identify pathways supporting the Myc oncogenic program, we employed a genome-wide RNAi screen for Myc-synthetic-lethal (MySL) genes and uncovered a role for the SUMO-activating-enzyme (SAE1/2). Loss of SAE1/2 enzyma...
ORGANISM(S): Homo sapiens 
2011-12-08 | E-GEOD-34055 | biostudies-arrayexpress
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