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GenomicsGenome-wide analysis of H3K4me1 in Lsh-/- mouse embryonic fibroblasts
We report here differentiated enrichment of H3K4me1 at Lsh WT and KO mouse embryonic fibroblasts (MEFs). We found a subset of differentially enriched H3K4me1 regions in Lsh KO MEFs, and they clustered at neuronal lineage genes and overlapping with known cis-regulatory elements present in brain tissu...
ORGANISM(S): Mus musculus 
2014-03-25 | E-GEOD-56151 | biostudies-arrayexpress
GenomicsGenome-wide analysis of next generation sequencing for Lsh+/+ and Lsh-/- mouse embryonic fibroblasts
To examine the relationship of reduced CG methylation and gene expression in Lsh KO MEFs, we computed mean CG methylation levels at promoter regions of protein-coding genes. About 60% of TSS regions of protein-coding genes display a difference of CG methylation values greater than 0.3 (WT CG methyla...
ORGANISM(S): Mus musculus 
2014-06-24 | E-GEOD-57419 | biostudies-arrayexpress
TranscriptomicsStrain-specific Innate Immune Signaling Pathways Determine Malaria Parasitemia Dynamics and Host Mortality
Malaria infection triggers vigorous host immune responses; however, the parasite ligands, host receptors and the signaling pathways responsible for these reactions remain unknown or controversial. Malaria parasites primarily reside within red blood cells (RBCs), thereby hiding themselves from direct...
ORGANISM(S): Mus musculus 
2014-01-13 | E-GEOD-51329 | biostudies-arrayexpress
GenomicsWhole genome shotgun bisulfite sequencing of the Lsh-/- and Lsh+/+ murine embryonic fibroblasts and ES cells
Whole-genome single-base resolution methylcytosine map reveals profound changes that occur after Lsh deletion during embryonic development in primary WT and Lsh-/- MEFs. Lsh deletion leads to widespread decreases of CG methylation level at uniquely mapped genomic regions compared to wild type, inclu...
ORGANISM(S): Mus musculus 
2014-06-13 | E-GEOD-57486 | biostudies-arrayexpress
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