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ProteomicsSDH deficiency-driven succinate accumulation dictates the drug resistance of AML through regulating p-UBC12/cullin activity
Drug resistance is vital for the poor prognosis of acute myeloid leukemia (AML) patients, but the underlying mechanism remains poorly understood. Given the unique microenvironment of bone marrow, we reasoned that drug resistance of AML might rely on distinct microenvironment-associated metabolic pro...
ORGANISM(S): Homo sapiens (Human) 
2024-08-28 | PXD047175 | Pride
Sdh deficiency  succinate  drug resistance  ubc12 phosphorylation  acute myeloid leukemia. 
UnknownGlobal prevalence of SARS-CoV-2 3CL protease mutations associated with nirmatrelvir or ensitrelvir resistance.
Not available
S-EPMC10101811 | biostudies-literature
UnknownSmilosicyopus leprurus (Teleostei: Gobiidae) is a Fin-eater.
Not available
S-EPMC6511814 | biostudies-literature
ModelsQi2013 - IL-6 and IFN crosstalk model
Qi2013 - IL-6 and IFN crosstalk model This model [BIOMD0000000544] describes the crosstalk between IFN-gamma and IL-6 induced signalling; it aims to outline mechanisms and factors that may control the interaction between both signalling pathways, discussing a role of heterodimer formation in signa...
2024-09-02 | BIOMD0000000544 | BioModels
ModelsQi2013 - IL-6 and IFN crosstalk model (non-competitive)
Qi2013 - IL-6 and IFN crosstalk model (non-competitive) This model [BIOMD0000000543] describes the crosstalk between IFN-gamma and IL-6 induced signalling; it aims to outline mechanisms and factors that may control the interaction between both signalling pathways, discussing a role of heterodimer f...
2024-09-02 | BIOMD0000000543 | BioModels
UnknownROS-responsive nano-drug delivery system combining mitochondria-targeting ceria nanoparticles with atorvastatin for acute kidney injury.
Not available
S-EPMC7019163 | biostudies-literature
UnknownSurgeon influence on use of needle biopsy in patients with breast cancer: a national medicare study.
Not available
S-EPMC4164811 | biostudies-literature
UnknownReverse genetics-derived cattle H5N1 virus from Clade 2.3.4.4b shows enhanced systemic infectivity and pathogenicity than an older Clade 1 H5N1 virus in BALB/c mice.
Not available
S-EPMC11915741 | biostudies-literature
ProteomicsTitle（Project name）Proteomic Investigation of the Molecular Mechanisms in Response to the PEG-Induced Drought Stress in Soybean Roots
Roots are generally the critical drought sensors, but little is known about their molecular response to drought stress. We used the drought-tolerant soybean variety ‘Jiyu 47’ to investigate the differentially expressed proteins (DEPs) in soybean roots during the seedling stage based on the TMT prote...
ORGANISM(S): Glycine max 
2022-05-08 | PXD033092 | Pride
Soybean root  drought stress  physiological response  proteomics  antioxidant  enrichment analysis 
UnknownROS-responsive chitosan-SS31 prodrug for AKI therapy via rapid distribution in the kidney and long-term retention in the renal tubule.
Not available
S-EPMC7546709 | biostudies-literature
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