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TranscriptomicsDNA methylation profiling of somatic tissues from normal and trisomic fetuses
The DNA methylation profiles in normal and abnormal fetal development were investigated using Illumina GoldenGate Methylation Cancer Panel I. DNA methylation status of 1505 CpG dinucleotides located in the regulatory regions of 807 genes was measured in 5 somatic tissues (brain, kidney, lung, muscle...
ORGANISM(S): Homo sapiens 
2011-05-06 | E-GEOD-25283 | biostudies-arrayexpress
TranscriptomicsCultured Cyto and Syncytio-trophoblast samples exposed to varying degrees of hypoxia (methylation)
The mechanisms by which the placenta adapts to exogenous stimuli to create a stable and healthy environment for the growing fetus are not well known. Low oxygen tension and sub-optimal vitamin D levels influence placental function and both are associated with preeclampsia, a condition associated wit...
ORGANISM(S): Homo sapiens 
2013-01-18 | E-GEOD-41336 | biostudies-arrayexpress
TranscriptomicsCultured Cyto and Syncytio-trophoblast samples exposed to varying degrees of hypoxia
This SuperSeries is composed of the SubSeries listed below. Refer to individual Series
ORGANISM(S): Homo sapiens 
2013-01-18 | E-GEOD-41341 | biostudies-arrayexpress
TranscriptomicsGenome-wide DNA methylation identifies trophoblast invasion-related genes: Claudin-4 and Fucosyltransferase IV control mobility via altering matrix metalloproteinase activity
Previously we have shown that extravillous cytotrophoblast (EVT) outgrowth and migration on a collagen gel explant model were restricted by exposure to decidual natural killer cells (dNK). This study investigates the molecular causes behind this phenomenon. Genome wide DNA methylation of exposed and...
ORGANISM(S): Homo sapiens 
2015-04-07 | E-GEOD-60885 | biostudies-arrayexpress
TranscriptomicsGenome-wide Mapping of Imprinted Genes by DNA Methylation Profiling of Human Placentas from Triploidies
Genome-wide DNA methylation profiling of placentas from diandric and digynic triploidies. DNA methylation profiles across more than 27,000 CpGs were obtained by using the Illumina Infinium 27k Human DNA methylation Beadchip v1.2. Placentas of 10 diandric and 10 digynic triploidies were included. Bis...
ORGANISM(S): Homo sapiens 
2011-06-30 | E-GEOD-25966 | biostudies-arrayexpress
TranscriptomicsEvidence for widespread changes in promoter methylation profile in human placenta in response to increasing gestational age and environmental/stochastic factors.
Background: the human placenta facilitates the exchange of nutrients, gas and waste between the fetal and maternal circulations. It also protects the fetus from the maternal immune response. Due to its role at the feto-maternal interface, the placenta is subject to many environmental exposures that ...
ORGANISM(S): Homo sapiens 
2011-08-31 | E-GEOD-31781 | biostudies-arrayexpress
TranscriptomicsDNA methylation in Early Onset Preeclamptic placentas
We investigated the DNA methylation and gene expression of 20 chorionic villi samples from early onset preeclampsia placentas to 20 gestational age matched controls. From this we were able to see a widespread disregulation in DNA methylation across a subset of genes in the genome. This may help to e...
ORGANISM(S): Homo sapiens 
2013-06-21 | E-GEOD-44667 | biostudies-arrayexpress
TranscriptomicsGene expression in Early-Onset Preeclampsia Placentas and Controls
We investigated the DNA methylation and gene expression of 20 chorionic villi samples from early onset preeclampsia placentas to 20 gestational age matched controls. From this we were able to see a widespread disregulation in DNA methylation across a subset of genes in the genome. This may help to e...
ORGANISM(S): Homo sapiens 
2013-06-21 | E-GEOD-44711 | biostudies-arrayexpress
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