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ProteomicsCombined Antibody/Lectin-Enrichment Identifies Extensive Changes in the O-GlcNAc Subproteome Upon Oxidative Stress
O-GlcNAc is thought to regulate proteins in a mannaer analogous to other PTMs, modulating cellular functions including the cellular stress response. The aim of this study was to identify specific cellular networks and protein complexes that are differentially O-GlcNAcylated and/or expressed upon acu...
ORGANISM(S): Mus musculus (Mouse) 
2016-09-29 | PXD000849 | Pride
Oxidative stress Affinity chromatography Silac O-glcnac 
ProteomicsQuantitative Proteomics Reveals that the OGT Interactome is Remodeled in Response to Oxidative Stress
The dynamic modification of specific serine and threonine residues of intracellular proteins by O-linked N-acetyl-β-D-glucosamine (O-GlcNAc) mitigates injury and promotes cytoprotection in a variety of stress models. The O-GlcNAc transferase (OGT) and the O-GlcNAcase (OGA) are the sole enzymes that ...
ORGANISM(S): Mus Musculus 
2021-04-05 | PXD021091 | panorama
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