Sort   by:  
 Page size 
TranscriptomicsRb deletion in mammary stem/progenitor epithelium induces tumors with features of luminal-B or basal-like breast cancer
The retinoblastoma tumor suppressor, Rb, is implicated in luminal-B and basal-like breast carcinomas, yet its effect on mammary gland development and causal role in breast cancer subtypes remain undefined. Here we show that conditional deletion of Rb in mouse mammary epithelium led to expansion of t...
ORGANISM(S): Mus musculus 
2010-07-06 | E-GEOD-14457 | biostudies-arrayexpress
TranscriptomicsaCGH data of Rb/p53 deficient mammary tumors
To investigate the impact of combined Rb and p53 loss in mammary tumorigenesis, we used transgenic and viral approaches to delete Rb and p53 floxed alleles specifically in the mouse mammary epithelium. Although MMTV-Cre (NLST) targets stem/bi-potent progenitors in the mammary gland, a subset of MM...
ORGANISM(S): Mus musculus 
2014-10-07 | E-GEOD-62101 | biostudies-arrayexpress
TranscriptomicsExpression data comparing Rb/p53 and p53 deficient mammary tumors and normal mammary tissue
To investigate the impact of combined Rb and p53 loss in mammary tumorigenesis, we used transgenic and viral approaches to delete Rb and p53 floxed alleles specifically in the mouse mammary epithelium. Although MMTV-Cre (NLST) targets stem/bi-potent progenitors in the mammary gland, a subset of MM...
ORGANISM(S): Mus musculus 
2014-10-03 | E-GEOD-62016 | biostudies-arrayexpress
TranscriptomicsExpression data comparing KRas(G12D/+);CreT, R26(H1047R/+);KRas(G12D/+);CreT, and MMTV-Neu mouse mammary tumors
Breast Cancer (BC) has been associated with alterations in signaling through a number of growth factor and hormone regulated pathways. Mouse models for metastatic BC have been developed using oncoproteins that activate PI3K, Stat3 and Ras signaling. To determine the role of each pathway, we analyz...
ORGANISM(S): Mus musculus 
2015-09-16 | E-GEOD-73073 | biostudies-arrayexpress
UnknownHypophosphorylated pRb knock-in mice exhibit hallmarks of aging and vitamin C-preventable diabetes
Not available
S-SCDT-EMBOJ-2020-106825P | biostudies-other
Sort   by:  
 Page size