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TranscriptomicsMolecular Signature of response and potential pathways related to resistance to the HSP90 inhibitor, 17-AAG, in breast cancer.
We have done transcriptional profiling of 17-AAG treated (24h, 48H) breast cancer cell lines to understand the mechanisms of the drug action and indicate novel set of pharmacodynamic biomarkers of the drug response as well as of resistance Two-condition experiment, Untreated vs. Treated sensitive c...
ORGANISM(S): Homo sapiens 
2010-10-11 | E-GEOD-23209 | biostudies-arrayexpress
TranscriptomicsIntegration of BRCA1-mediated miRNA and mRNA signatures reveal miR-146a, miR-99b and miR-205 regulation of the TRAF2 and NFkB pathways (mRNA dataset)
BRCA1 deregulation is a frequent event in the pathogenesis of breast as well as other cancers. In addition to the DNA repair functions of BRCA1, it is involved in a wide range of cellular processes such as cell cycle, chromatin remodeling or transcription. However, the molecular events underlying BR...
ORGANISM(S): Homo sapiens 
2011-12-24 | E-GEOD-30821 | biostudies-arrayexpress
TranscriptomicsTranscription profiling of human nodal peripheral T-cell lymphomas
Microarray technology was used to monitor the level of expression of 7,657 human genes in a set of 35 nodal peripheral T-cell lymphomas.
ORGANISM(S): Homo sapiens 
2007-01-30 | E-TABM-191 | biostudies-arrayexpress
TranscriptomicsIntegration of BRCA1-mediated miRNA and mRNA signatures reveal miR-146a, miR-99b and miR-205 regulation of the TRAF2 and NFkB pathways (miRNA dataset)
Microarray?based techniques are being used to obtain miRNA and gene expression signatures associated with different samples. In order to deepen our understanding of BRCA1-associated tumorigenesis, we integrated data from microarray experiments to obtain significant miRNA-mRNA relationships associate...
ORGANISM(S): Homo sapiens 
2011-12-24 | E-GEOD-30763 | biostudies-arrayexpress
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