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ProteomicsIdentification of the covalent binding site of Ibrutinib and 5Z-7-Oxozeaenol to ZAK
The goal of this experiment was to identify the reaction site of Ibrutinib and 5Z-7-Oxozeaenol to ZAK by determination of mass shifts according to a covalent modification by the inhibitors using mass spectrometry.
ORGANISM(S): Homo sapiens (Human) 
2017-10-13 | PXD007752 | Pride
Ibrutinib 5z-7-oxozeaenol Cys150 Recombinant zak Cys22 Covalent modification 
GenomicsZAK activation at the collided ribosome
ZAK activation at the collided ribosome
PRJNA1273921 | ENA
ModelsTang2019 - Pharmacology modelling of AURKB and ZAK interaction in TNBC
Aurora Kinase B and ZAK interaction model Equivalent of the stochastic model used in "Network pharmacology model predicts combined Aurora B and ZAK inhibition in MDA-MB-231 breast cancer cells" by Tang et. al. 2018. The only difference is cell division and partitioning of the components, which a...
2024-09-02 | BIOMD0000000940 | BioModels
OtherZAK activation at the collided ribosome
Ribosome collisions activate the ribotoxic stress response mediated by the MAP3K ZAK, which in turn regulates cell-fate consequences through downstream phosphorylation of the MAPKs p38 and JNK1. Despite the critical role of ZAK during cellular stress, a mechanistic and structural understanding of ZA...
ORGANISM(S): Homo sapiens 
2025-10-02 | GSE299329 | GEO
ProteomicsThe ribotoxic stress response drives UV-mediated cell death.
Supporting raw MS data for paper (doi: 10.1016/j.cell.2024.05.018) by Sinha N.K. et al, titled "The ribotoxic stress response drives UV-mediated cell death". Index of MS files and labels Table S1 - HaCaT Timecourse. 1-1 - Proteome (AO3604-3627 | Unimod:35; 2016; 4 | 126 -UT_01; 127n - UT_02; 12...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2023-07-25 | MSV000092521 | MassIVE
UnknownZAK activation at the collided ribosome.
Not available
S-EPMC12823453 | biostudies-literature
GenomicsROS-induced translation impairment underlies ZAK-mediated metabolic decline in obesity and aging
ROS-induced translation impairment underlies ZAK-mediated metabolic decline in obesity and aging
PRJNA986928 | ENA
GenomicsZAK-alpha is a sensor of mRNA stasis at the ribosomal exit channe
ZAK-alpha is a sensor of mRNA stasis at the ribosomal exit channe
PRJNA1390200 | ENA
GenomicsZAK activation on colliding ribosomes triggers SAPK signaling pathways to regulate cell fate
ZAK activation on colliding ribosomes triggers SAPK signaling pathways to regulate cell fate
PRJNA593553 | ENA
UnknownA Novel Zak Knockout Mouse with a Defective Ribotoxic Stress Response.
Not available
S-EPMC5037485 | biostudies-literature
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