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TranscriptomicsProtective role of Apolipoprotein E in experimental acute renal allogaft rejection
Objective: Apolipoprotein E (Apo E) is a multifunctional protein, originally described in the context of lipoprotein metabolism and cardiovascular disease. More recently, anti-inflammatory functions of ApoE have been documented. ApoE was studied in the context of several inflammatory disorders, but ...
ORGANISM(S): Rattus norvegicus 
2016-06-01 | E-GEOD-58156 | biostudies-arrayexpress
TranscriptomicsLeukocyte accumulation in graft blood vessels during self-limiting acute rejection of rat kidneys Immunobiology
Acute rejection episodes trigger chronic renal allograft vasculopathy. Numerous leukocytes, predominantly monocytes, accumulate in graft blood vessels during reversible acute rejection preceding chronic rejection of rat kidneys. We speculate that they contribute to transplant vasculopathy and set ou...
ORGANISM(S): Rattus norvegicus 
2010-09-24 | E-GEOD-18266 | biostudies-arrayexpress
TranscriptomicsIl13-stimulation of human paSMCs
Idiopathic pulmonary arterial hypertension (IPAH) is characterized by medial hypertrophy due to pulmonary arterial smooth muscle cell (paSMC) hyperplasia. Interleukin (IL)-13 is a potent regulator of tissue fibrosis and remodelling, and its effects are dependent on the cell-type specific expression ...
ORGANISM(S): Homo sapiens 
2010-05-07 | E-GEOD-15739 | biostudies-arrayexpress
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