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TranscriptomicsSingle cell analysis of the Common Lymphoid Progenitor compartment reveals functional and molecular heterogeneity
In order to investigate molecular events involved in the regulation of lymphoid lineage commitment, we crossed lamda5 reporter transgenic mice to mice where the GFP gene is inserted into the Rag1 locus. This allowed us to sub-fractionate common lymphoid progenitors (CLPs) and pre-pro-B cells into la...
ORGANISM(S): Mus musculus 
2009-11-24 | E-GEOD-19142 | biostudies-arrayexpress
TranscriptomicsThe transcriptional architecture of early human hematopoiesis identifies multilevel control of lymphoid commitment.
Here we tracked transcriptome changes over ten human hematopoietic stem and early progenitor populations, defining the transcriptional dynamics underlying the first steps of commitment. Most of the transcriptional programs observed extended beyond lineage boundaries. In particular, multi-lymphoid pr...
ORGANISM(S): Homo sapiens 
2013-05-26 | E-GEOD-42414 | biostudies-arrayexpress
TranscriptomicsInteractions between developing B-lymphocytes and stromal cells reveal complex interactions and two-way communication
Full title: Genomics based analysis of interactions between developing B-lymphocytes and stromal cells reveal complex interactions and two-way communication In order to identify extra cellular signals that promote B lymphocyte development we created a database with approximately 400 receptor ligand...
ORGANISM(S): Mus musculus 
2010-01-05 | E-GEOD-19729 | biostudies-arrayexpress
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