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UnknownBeta-adrenergic receptor polymorphisms and cardiac graft function in potential organ donors.
Prior studies have demonstrated associations between beta-adrenergic receptor (βAR) polymorphisms and left ventricular dysfunction-an important cause of allograft nonutilization for transplantation. We hypothesized that βAR polymorphisms predispose donor hearts to LV dysfunction after brain death. A...
S-EPMC3513582 | biostudies-literature
UnknownCommon variants on 9p21.3 are associated with brain arteriovenous malformations with accompanying arterial aneurysms.

Objective

To investigate whether previously reported 9p21.3 single nucleotide polymorphisms (SNPs) are associated with risk of brain arteriovenous malformations (BAVM), which often have accompanying arterial aneurysms. Common variants in the 9p21.3 locus have been reported to be associated w...
S-EPMC4201968 | biostudies-literature
UnknownIncidence, Predictors, and Outcomes Associated With Worsening Renal Function in Patients With Heart Failure and Secondary Mitral Regurgitation: The COAPT Trial.
Background The incidence and implications of worsening renal function (WRF) after mitral valve transcatheter edge-to-edge repair (TEER) in patients with heart failure (HF) are unknown. Therefore, the aim of this study was to determine the proportion of patients with HF and secondary mitral regurgita...
S-EPMC10382100 | biostudies-literature
UnknownGenome-wide association study of intracranial aneurysms identifies 17 risk loci and genetic overlap with clinical risk factors.
Rupture of an intracranial aneurysm leads to subarachnoid hemorrhage, a severe type of stroke. To discover new risk loci and the genetic architecture of intracranial aneurysms, we performed a cross-ancestry, genome-wide association study in 10,754 cases and 306,882 controls of European and East Asia...
S-EPMC7116530 | biostudies-literature
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