Sort   by:  
 Page size 
UnknownSuppression of a fusion defect by second site mutations in the ecotropic murine leukemia virus surface protein.
Entry of ecotropic murine leukemia virus initiates when the envelope surface protein recognizes and binds to the virus receptor on host cells. The envelope transmembrane protein then mediates fusion of viral and host cell membranes and penetration into the cytoplasm. Using a genetic selection, we is...
S-EPMC112548 | biostudies-literature
UnknownPim2 is required for maintaining multiple myeloma cell growth through modulating TSC2 phosphorylation.
Multiple myeloma (MM) is the second most common hematologic malignancy. Despite recent treatment advances, it remains incurable. Here, we report that Pim2 kinase expression is highly elevated in MM cells and demonstrate that it is required for MM cell proliferation. Functional interference of Pim2 a...
S-EPMC3953014 | biostudies-literature
UnknownA novel small molecule inhibitor of CD73 triggers immune-mediated multiple myeloma cell death.
Not available
S-EPMC11004003 | biostudies-literature
UnknownStructure Guided Optimization, in Vitro Activity, and in Vivo Activity of Pan-PIM Kinase Inhibitors.
Proviral insertion of Moloney virus (PIM) 1, 2, and 3 kinases are serine/threonine kinases that normally function in survival and proliferation of hematopoietic cells. As high expression of PIM1, 2, and 3 is frequently observed in many human malignancies, including multiple myeloma, non-Hodgkins lym...
S-EPMC4027555 | biostudies-literature
UnknownInhibition of prenylated KRAS in a lipid environment.
RAS mutations lead to a constitutively active oncogenic protein that signals through multiple effector pathways. In this chemical biology study, we describe a novel coupled biochemical assay that measures activation of the effector BRAF by prenylated KRASG12V in a lipid-dependent manner. Using this ...
S-EPMC5383040 | biostudies-literature
Sort   by:  
 Page size