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TranscriptomicsCharacterization of the transcriptional response to hypoxia in MDA-MB-231-shCAIX, MCF7-shCAIX and the respective control cells grown as multicellular spheroids under hypoxic or normoxic conditions
To interrogate the hypoxia response pathways affected by the depletion of CAIX in BC cells, we performed gene expression profiling using SurePrint G3 Human Gene Expression 60K microarrays in MDA-MB-231-shCAIX, MCF7-shCAIX and the respective control cells grown as multicellular spheroids under hypoxi...
ORGANISM(S): Homo sapiens 
2018-01-01 | E-MTAB-5512 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of tissue and plasma extracellular vesicles of breast cancer patients at the time of diagnosis and after the breast surgery
In the current study, we performed deep sequencing analysis of the RNA cargo of plasma EVs collected at the time of diagnosis, during and after the NAC and up to 18 months after the surgery and matched tumor and normal tissues from 35 patients with locally advanced BC, and 30 cancer-free females.
ORGANISM(S): Homo sapiens 
2022-10-24 | E-MTAB-12014 | biostudies-arrayexpress
TranscriptomicsRNA-Seq of Tissue, Plasma and Urinary Extracellular Vesicles of Prostate Cancer patients
We performed RNA-Seq analysis of plasma and urinary EVs collected before and after radical prostatectomy, and matched tumor and normal prostate tissues of 10 patients with prostate cancer. To identify putative cancer-derived RNA biomarkers, we searched for RNAs that were overexpressed in tumor as co...
ORGANISM(S): Homo sapiens 
2022-11-16 | E-MTAB-11910 | biostudies-arrayexpress
TranscriptomicsThe analysis of transcriptional profiles of cybrid cells harbouring two pathogenic mtDNA variants associated with Leigh syndrome
The analysis of transcriptional profiles of cybrid cells harbouring two pathogenic mtDNA variants associated with Leigh syndrome i.e., m.9185T>C in the mt-ATP6 gene and m.13513G>A in the mt-ND5 gene, in comparison to cybrid cells harbouring control mtDNA haplogroups or the wt m.13513G variant.
ORGANISM(S): Homo sapiens 
2023-04-01 | E-MTAB-11035 | biostudies-arrayexpress
TranscriptomicsEffects of urinary extracellular vesicles from prostate cancer patients on the transcriptomes of cancer-associated and normal fibroblasts
Patient-derived prostate fibroblast primary cultures PCF-54 and PCF-55 were established from two specimens of PC tissues. EVs were isolated from urine samples of 3 patients with PC and 2 healthy males and used for the treatment of prostate fibroblast primary cultures and normal foreskin fibroblasts....
ORGANISM(S): Homo sapiens 
2023-04-01 | E-MTAB-11022 | biostudies-arrayexpress
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