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GenomicsRNAseq of Zcchc8 mutant mouse embryonic heads
RNAseq of Zcchc8 mutant mouse embryonic heads
PRJNA521035 | ENA
TranscriptomicsRNAseq of Zcchc8 mutant mouse embryonic heads
We identified a germline heterozygous loss-of-function mutation in ZCCHC8, an RNA exosome targeting component, in a family with autosomal dominant pulmonary fibrosis and telomerase RNA insufficiency. To understand the in vivo consequences of Zcchc8 loss, we targeted the gene locus. Zccchc8+/- showed...
ORGANISM(S): Mus musculus 
2019-10-01 | GSE126108 | GEO
UnknownZCCHC8 p.P410A disrupts nucleocytoplasmic localization, promoting idiopathic pulmonary fibrosis and chronic obstructive pulmonary disease.
Not available
S-EPMC11389302 | biostudies-literature
GenomicsZCCHC8 is required for the degradation of pervasive transcripts originating from multiple genomic regulatory features
ZCCHC8 is required for the degradation of pervasive transcripts originating from multiple genomic regulatory features
PRJNA695456 | ENA
UnknownStructural basis for MTR4-ZCCHC8 interactions that stimulate the MTR4 helicase in the nuclear exosome-targeting complex.
Not available
S-EPMC6004480 | biostudies-literature
GenomicsNuclear exosome targeting complex core factor Zcchc8 regulates the degradation of LINE1 RNA in early embryos and embryonic stem cells
Nuclear exosome targeting complex core factor Zcchc8 regulates the degradation of LINE1 RNA in early embryos and embryonic stem cells
PRJNA525408 | ENA
UnknownA new variant in the ZCCHC8 gene: diverse clinical phenotypes and expression in the lung.
Not available
S-EPMC10875464 | biostudies-literature
UnknownZCCHC8, the nuclear exosome targeting component, is mutated in familial pulmonary fibrosis and is required for telomerase RNA maturation.
Not available
S-EPMC6771387 | biostudies-literature
UnknownStructure of the RBM7-ZCCHC8 core of the NEXT complex reveals connections to splicing factors.
Not available
S-EPMC5146272 | biostudies-literature
TranscriptomicsNuclear exosome targeting complex core factor Zcchc8 regulates the degradation of LINE1 RNA in early embryos and embryonic stem cells
The nuclear exosome targeting (NEXT) complex is responsible for recruiting RNA exosomes to degrade specific nuclear RNAs in mammalian cells. However, its function in mammalian development remains unknown. Here, we found that the depletion of a central factor of the NEXT complex, Zcchc8, resulted in ...
ORGANISM(S): Mus musculus 
2019-11-07 | GSE127790 | GEO
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