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UnknownShannon information theoretic computation of synonymous codon usage biases in coding regions of human and mouse genomes.
Not available
S-EPMC1383734 | biostudies-literature
TranscriptomicsGenome-wide analysis of novel splice variants induced by topoisomerase I poisoning shows preferential occurrence in genes encoding splicing factors
Topoisomerase I (Top1) relaxes both positive and negative supercoilings by producing transient Top1 cleavage complexes (Top1cc). Several studies have suggested the implication of Top1 in splicing. Here, we tested the implication of Top1cc in splicing at the global genome level in human carcinoma cel...
ORGANISM(S): Homo sapiens 
2011-07-21 | E-GEOD-23677 | biostudies-arrayexpress
UnknownHigh-Throughput GoMiner, an 'industrial-strength' integrative gene ontology tool for interpretation of multiple-microarray experiments, with application to studies of Common Variable Immune Deficiency (CVID).
Not available
S-EPMC1190154 | biostudies-literature
TranscriptomicsTranscription poisoning by topoisomerase I is controlled by gene length, splice sites and miR-142-3p
DNA topoisomerase I (Top1) is required for transcription as it relaxes positive and negative supercoils by forming transient Top1 cleavage complexes (Top1cc) up- and down-stream of transcription complexes. However, Top1cc can also be trapped by endogenous DNA lesions and by camptothecin (CPT) and it...
ORGANISM(S): Homo sapiens 
2013-04-17 | E-GEOD-37352 | biostudies-arrayexpress
TranscriptomicsTopoisomerase I cleavage complexes preferentially down-regulate ubiquitin- and RNA degradation-related transcripts in relationship to gene length, exon-intron junctions and p53-dependent up-regulation of miR-142-3p [miRNA]
DNA topoisomerase I (Top1) is required for transcription as it relaxes positive and negative supercoils by forming transient Top1 cleavage complexes (Top1cc) up- and down-stream of transcription complexes. However, Top1cc can also be trapped by endogenous DNA lesions and by camptothecin (CPT) and it...
ORGANISM(S): Homo sapiens 
2013-04-17 | E-GEOD-37357 | biostudies-arrayexpress
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