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TranscriptomicsCell types in the mouse amygdala and their transcriptional response to fear conditioning
We performed single-cell RNA-seq of full, microdissected and dissociated mouse amygdala, 2h, 8h or 24h after tone-cued fear conditioning (CFC), and 2h after recall (exposure to CS only, 24h post-CFC), and naive homecage controls.
ORGANISM(S): Mus musculus 
2023-01-01 | E-MTAB-12096 | biostudies-arrayexpress
TranscriptomicsRNA-seq analysis of single cells of the oligodendrocyte lineage from nine distinct regions of the anterior-posterior and dorsal-ventral axis of the mouse juvenile central nervous system
5069 transcriptomes of single oligodendrocyte cells from spinal cord, substantia nigra-ventral tegmental area, striatum, amygdala, hypothalamic nuclei, zona incerta, hippocampus, and somatosensory cortex of male and female mice between post-natal day 21 and 90. The study aimed at identifying diverse...
ORGANISM(S): Mus musculus 
2016-06-10 | E-GEOD-75330 | biostudies-arrayexpress
TranscriptomicsCircadian regulation of EGF-receptor signaling by glucocorticoids
Transcriptional responses to stimuli are regulated by tuning rates of transcript production and degradation. Here we show that stimulation-induced changes in transcript production and degradation rates can be inferred from simultaneously measured precursor mRNA (pre-mRNA) and mature mRNA profiles. O...
ORGANISM(S): Homo sapiens 
2014-08-30 | E-GEOD-53405 | biostudies-arrayexpress
TranscriptomicsSingle-cell RNA-seq of mouse cerebral cortex
We have applied a recently developed, highly accurate and sensitive single-cell RNA-seq method (STRT/C1) to perform a molecular census of two regions of the mouse cerebral cortex: the somatosensory cortex and hippocampus CA1. We isolated cells fresh from somatosensory cortex (S1) and hippocampus CA1...
ORGANISM(S): Mus musculus 
2015-02-20 | E-GEOD-60361 | biostudies-arrayexpress
TranscriptomicsBMP-mediated inhibition of FGF signaling promotes cardiomyocyte differentiation of anterior heart field progenitors
The transition from progenitor to differentiated cells is critical for successful organogenesis; subtle alterations in this process can lead to developmental disorders. The anterior heart field (AHF) encompasses a niche in which cardiac progenitors maintain their multipotent and undifferentiated nat...
ORGANISM(S): Gallus gallus 
2010-08-01 | E-GEOD-19698 | biostudies-arrayexpress
TranscriptomicsQuantitative single-cell RNA-seq
Purpose: We applied cDNA molecule counting using unique molecular identifiers combined with high-throughput sequencing to study the transcriptome of individual mouse embryonic stem cells, with spike-in controls to monitor technical performance. We further examined transcriptional noise in the embryo...
ORGANISM(S): Mus musculus 
2013-12-20 | E-GEOD-46980 | biostudies-arrayexpress
TranscriptomicsEffect of EGF and/or HER2 on the growth of MCF10A cells on extracellular matrix: time course
Mammary epithelial cells MCF10A and HER2 overexpressing MCF10A cells were grown on matrigel in the absence or presence of epidermal growth factor. Cells were lysed and RNA was collected at 1.5,3,5,7,9 days. Total 20 arrays from four time course experiments. MCF10A and MCF10A-HER2 (overexpressed H...
ORGANISM(S): Homo sapiens 
2011-07-29 | E-GEOD-18938 | biostudies-arrayexpress
TranscriptomicsImplantation Failure of Blastocysts Derived from Oocyte-directed Connexin 43 depleted Mice is Associated with Impaired Ribosomal and Translational Machinery Gene Expression
Oocyte quality is a well- established determinant of embryonic fate. However, the molecular participants and biological markers that affect and predict adequate embryonic development are largely elusive. We have previously reported that oocyte- directed Connexin 43 (Cx43) depletion leads to embryo i...
ORGANISM(S): Mus musculus 
2013-01-01 | E-GEOD-35299 | biostudies-arrayexpress
TranscriptomicsCoupled pre-mRNA and mRNA dynamics unveil the operation strategies underlying transcriptional responses
Transcriptional responses to stimuli are regulated by tuning rates of transcript production and degradation. Here we show that stimulation-induced changes in transcript production and degradation rates can be inferred from simultaneously measured precursor mRNA (pre-mRNA) and mature mRNA profiles. O...
ORGANISM(S): Homo sapiens 
2011-08-30 | E-GEOD-24391 | biostudies-arrayexpress
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