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TranscriptomicsAmplification and overexpression of vinculin are associated with increased tumor cell proliferation and progression in advanced prostate cancer
We analyzed the 10q22 amplification in advanced prostate cancer and subjected the genes located in the common amplified region to an RNAi screen. We found vinculin as the most promising candidate gene and analyzed its protein expression on more than 400 prostate cancers by using the tissue micrarray...
ORGANISM(S): Homo sapiens 
2011-02-08 | E-GEOD-24216 | biostudies-arrayexpress
TranscriptomicsAdvancing a Clinically Relevant Perspective of the Clonal Nature of Cancer
We used DNA content-based flow cytometry to distinguish and isolate nuclei from clonal populations in primary tissues from three disparate cancers with variable clinical histories. We then developed a methodology to adapt flow cytometrically purified nuclei samples for use with whole genome technolo...
ORGANISM(S): Homo sapiens 
2011-07-04 | E-GEOD-21660 | biostudies-arrayexpress
TranscriptomicsSTAG2 is a clinically relevant tumor suppressor in pancreatic ductal adenocarcinoma
STAG2 is targeted by somatic aberrations in a subset (4%) of human PDAs. Transposon mediated disruption of STAG2 in a KRASG12D genetically engineered mouse model promotes the development of PDA and its progression to metastatic disease. There was a statistically significant loss of STAG2 protein exp...
ORGANISM(S): Homo sapiens 
2014-01-24 | E-GEOD-54328 | biostudies-arrayexpress
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