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UnknownEGF regulation of proximal tubule cell proliferation and VEGF-A secretion.
Proximal tubule cell (PTC) proliferation is critical for tubular regeneration and recovery from acute kidney injury. Epidermal growth factor (EGF) and vascular endothelial growth factor (VEGF-A) are important for the maintenance of tubulointerstitial integrity and can stimulate PTC proliferation. We...
S-EPMC5617933 | biostudies-literature
UnknownPersistent increase in mitochondrial superoxide mediates cisplatin-induced chronic kidney disease.
Severe and recurrent cisplatin-induced acute kidney injury (AKI) as part of standard cancer therapy is a known risk factor for development of chronic kidney disease (CKD). The specific role of superoxide (O2•-)-mediated disruption of mitochondrial oxidative metabolism in CKD af...
S-EPMC6174865 | biostudies-literature
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