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ProteomicsSuccinyl-proteome profiling reveals HDAC8-mediated CAPZB desuccinylation regulates cytoskeleton remodeling in bleomycin-induced idiopathic pulmonary fibrosis
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive lung disease of unknown etiology, characterized by progressive scarring and fibrosis of the lungs, leading to irreversible loss of lung function. Current mechanism studies have found that fibroblasts, as the main effector cells, exhibit ab...
ORGANISM(S): Mus musculus (Mouse) 
2026-04-30 | PXD075455 | Pride
Idiopathic pulmonary fibrosis  lysine succinylation  succinyl-proteome  capzb  hdac8  cytoskeleton remodeling  lc-ms/ms  mouse lung tissue 
MetabolomicsAltered metabolome and microbiome features provide clues in understanding irritable bowel syndrome and depression comorbidity

Irritable bowel syndrome (IBS) is one of the functional gastrointestinal disorders characterized by chronic and/or recurrent symptoms of abdominal pain and irregular defecation. Changed gut microbiota has been proposed to mediate IBS; however, contradictory results exist, and IBS-specific microbi...

2021-12-01 | MTBLS2774 | MetaboLights
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