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Screening reveals that a zinc transporter Zip7 was upregulated in metastatic PCa and related to poor progression. Zip7 silencing inhibits PCa cell migration and invasion in vitro and bone-metastasis in vivo. Mechanistically, we identify that Zip7 mainly interacts with MAZ in cytoplasm to facilita...
ORGANISM(S): Homo Sapiens 
2026-01-14 | PXD073047 |
Esophageal cancer is one of the most aggressive cancers and the sixth leading cause of cancer death worldwide1. Approximately 70% of the global esophageal cancers occur in China and over 90% histopathological forms of this disease are esophageal squamous cell carcinoma (ESCC)2-3. Currently, there ar...
Esophageal cancer is one of the most aggressive cancers and the sixth leading cause of cancer death worldwide1. Approximately 70% of the global esophageal cancers occur in China and over 90% histopathological forms of this disease are esophageal squamous cell carcinoma (ESCC)2-3. Currently, there ar...
The key transcription factors that control the embryonic stem cell gene expression program have been identified, but how they function to implement this program is not well understood. While screening for genes essential for maintenance of ES cell state, we identified many components of the Mediato...
ORGANISM(S): Mus musculus 
Extracellular vesicles (EVs) are specialized nanoscale vesicular structures that act as mediators of intercellular communication, playing crucial roles in the pathological processes of cancers. Aberrant glycosylation is a hallmark of cancer, the analysis of EVs and protein glycosylation provides val...
ORGANISM(S): Homo Sapiens 
2025-03-24 | PXD062160 |
Vascular smooth muscle cells (VSMCs) within atherosclerotic lesions undergo a phenotypic switching in a KLF4-dependent manner. Glycolysis plays important roles in transdifferentiation of somatic cells, however, it is unclear whether and how KLF4 mediates the link between glycolytic switch and VSMCs ...
ORGANISM(S): Homo Sapiens 
2022-11-09 | PXD038057 |
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