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ProteomicsGPX4-dependent Glutathione (GSH) high consumption drives platinum chemotherapeutic resistance by inhibiting ferroptosis in lung cancer derived brain metastasis
Platinum-based chemotherapy is effective in inducing shrinkage of primary lung cancer lesions; however, it shows limited therapeutic efficacy in patients with brain metastasis (BM). In this study, we utilized a BM model of PC9 lung adenocarcinoma cells and found that the derivative brain metastatic ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD019571 | Pride
Lung cancer  brain metastasis  chemotherapeutic resistance  ferroptosis  glutathione metabolism  gpx4 
ProteomicsGPX4-dependent Glutathione (GSH) high consumption drives platinum chemotherapeutic resistance by inhibiting ferroptosis in lung cancer derived brain metastasis
Platinum-based chemotherapy is effective in inducing shrinkage of primary lung cancer lesions; however, it shows limited therapeutic efficacy in patients with brain metastasis (BM). In this study, we utilized a BM model of PC9 lung adenocarcinoma cells and found that the derivative brain metastatic ...
ORGANISM(S): Homo sapiens (Human) 
2022-02-15 | PXD019638 | Pride
Lung cancer  brain metastasis  chemotherapeutic resistance  ferroptosis  glutathione metabolism  gpx4 
ProteomicsComparative analysis of maca (Lepidium meyenii) proteome profiles reveals insights into response mechanisms of herbal plants to high-temperature stress
High-temperature stress (HTS) is one of the main environmental stresses that limit plant growth and crop production in agricultural systems. Maca (Lepidium meyenii) is an important high-altitude herbaceous plant adapted to a wide range of environmental stimuli such as cold, strong wind and UV-B expo...
ORGANISM(S): Lepidium meyenii 
2020-08-25 | PXD021042 | Pride
High-temperature stress Stress response Tandem mass tag Molecular mechanism Maca 
TranscriptomicsGene expression data of untreated and RA-treated wild type and RXRα-deficient mice liver
Our project focuses on retinoic acid (RA) effect on hepatic lipid homeostasis. Even though RA has more than one receptor including retinoids x receptor (RXR) and retinoic acid receptor (RAR), most probably, RA effect on lipid homeostasis is mediated by RXR and its partners such as PXR, FXR, and PPAR...
ORGANISM(S): Mus musculus 
2013-08-21 | E-GEOD-50028 | biostudies-arrayexpress
MetabolomicsPRODH regultes naive pluripotency by influencing mitochondrial oxidative phosphorylation (Untargeted metabolomics)

Naïve human embryonic stem cells (hESCs) that resemble the pre-implantation epiblasts are fueled by a combination of aerobic glycolysis and oxidative phosphorylation, but their mitochondrial regulators are poorly understood. Here we report that, proline dehydrogenase (PRODH), a mitochondria-local...

2024-02-12 | MTBLS7840 | MetaboLights
UnknownTargeted mutagenesis in the medicinal plant Salvia miltiorrhiza.
Not available
S-EPMC5335714 | biostudies-literature
UnknownCausal relationship between lipidome and acute respiratory distress syndrome.
Not available
S-EPMC11603036 | biostudies-literature
UnknownOleoylethanolamide Alleviates Hepatic Ischemia-Reperfusion Injury via Inhibiting Endoplasmic Reticulum Stress-Associated Apoptosis.
Not available
S-EPMC8960015 | biostudies-literature
UnknownPreparation of a Brucella multiepitope fusion protein based on bioinformatics and its application in serological diagnosis of human brucellosis
Not available
S-EPMC12125174 | biostudies-literature
UnknownSensitivity of SARS-CoV-2 to different temperatures.
Not available
S-EPMC7824962 | biostudies-literature
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