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MetabolomicsCharacterizing COPD phenotypes with a targeted signaling lipids metabolomics approach

A targeted metabolomics approach reveals distinct metabolic patterns associated with different GOLD stages, KNGF profiles and SYS subtypes in COPD patients, highlighting unique mechanisms and pathways underlying various COPD classification systems.

2025-07-21 | MTBLS11748 | MetaboLights
TranscriptomicsGene Bionetworks Involved in Epigenetic Transgenerational Inheritance of Environmentally Altered Sexual Selection: Role of Epigenetics in Evolutionary Biology
Sexual selection involves mate preference behavior and is a critical determinant for natural selection and evolutionary biology. Previously an environmental compound (fungicide vinclozolin) was found to promote epigenetic transgenerational inheritance of modified mate selection characteristics in al...
ORGANISM(S): Rattus norvegicus 
2012-03-01 | E-GEOD-33830 | biostudies-arrayexpress
MetabolomicsNormalization strategies for lipidome data in cell line panels & Distinct lipidomic profiles in breast cancer cell lines relate to proliferation and EMT phenotypes

Sample collection can significantly affect measurements of relative lipid concentrations in cell line panels, hiding intrinsic biological properties of interest between cell lines. Most quality control steps in lipidomic data analysis focus on controlling technical variation. Correcting for the t...

2025-08-07 | MTBLS9493 | MetaboLights
TranscriptomicsEfficient engineering of human and mouse primary cells using peptide-assisted genome editing
Simple and efficient delivery of CRISPR genome editing systems in primary cells remains a major challenge. Here, we describe an engineered Peptide-Assisted Genome Editing (PAGE) CRISPR-Cas system for rapid and robust editing of primary cells. PAGE couples a cell-penetrating Cas protein with a cell-p...
ORGANISM(S): Homo sapiens 
2023-03-20 | GSE223805 | GEO
UnknownGenome-wide identification and functional characterization of alpha-amylase genes in Litopenaeus vannamei.
Not available
S-EPMC12798967 | biostudies-literature
UnknownDevelopment and evaluation of a decision aid for family surrogate decision-makers for patients with acute kidney injury requiring renal replacement therapy (RRT) in ICUs: a study protocol.
Not available
S-EPMC7883861 | biostudies-literature
UnknownTruncation of the unique N-terminal domain improved the thermos-stability and specific activity of alkaline α-amylase Amy703.
Not available
S-EPMC4772547 | biostudies-literature
TranscriptomicsTranscription profiling of primary human keratinocytes
Oncogenic Ras induces epidermal cell growth arrest. Induction of the JNK/Ap1 signaling cascade by expression of MKK7 overcomes Ras-induced cell growth arrest in a manner dependent on AP1 fucntion. We used microarrays to detail the global programme of gene expression in response to MKK7, Ras activat...
ORGANISM(S): Homo sapiens 
2008-06-14 | E-GEOD-6559 | biostudies-arrayexpress
UnknownThe accuracy and effectiveness of automatic pedicle screw trajectory planning based on computer tomography values: an in vitro osteoporosis model study.
Not available
S-EPMC8862578 | biostudies-literature
Transcriptomics21T series cell lines show distinct stage-specific gene expression alterations
Pathologic and epidemiologic evidence has led to a histologic model of breast cancer progression that involves advancement through specific morphologic stages including atypical ductal hyperplasia (ADH), ductal carcinoma in situ (DCIS) and invasive mammary carcinoma (IMC), although not necessarily a...
ORGANISM(S): Homo sapiens 
2010-04-06 | E-GEOD-18370 | biostudies-arrayexpress
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