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TranscriptomicsExpression data from RUNX1(41-214)-expressing and Runx1-knockout mice KSL cells
Mutations of RUNX1 are detected in patients with myelodysplastic syndrome (MDS). In particular, C-terminal truncation mutations lack a transcription regulatory domain and have increased DNA binding through the runt homology domain (RHD). The expression of the RHD, RUNX1(41-214), in mouse hematopoiet...
ORGANISM(S): Mus musculus 
2012-11-29 | E-GEOD-40155 | biostudies-arrayexpress
TranscriptomicsPRMT1 interacts with leukemia fusion protein AML1-ETO for activation of transcription and transformation
Fusion protein AML1-ETO resulted from t(8;21) translocation is highly related to leukemia development. We have previously shown that the expression of AE9a, a spliced form of AML1-ETO, can rapidly cause leukemia in mouse. To understand how AML1-ETO is involved in leukemia development, we used AE9a l...
ORGANISM(S): Homo sapiens 
2012-06-17 | E-GEOD-28135 | biostudies-arrayexpress
TranscriptomicsExpression profiling of primary leukemia initiating cell-enriched population induced by AML1-ETO9a
Combined gene expression and DNA occupancy profiling identifies JAK/STAT signaling as a valid therapeutic target of t(8;21) AML t(8;21) is commonly associated with acute myeloid leukemia (AML). The resulting AML1-ETO fusion proteins are involved in the pathogenesis of AML. To identify novel molecul...
ORGANISM(S): Mus musculus 
2012-09-04 | E-GEOD-15195 | biostudies-arrayexpress
GenomicsWhole Genome Sequencing of a Triple Negative Breast Cancer Patient: Matched Primary Tumor, Normal, Metastasis and Xenograft samples

Breast Cancer Subject Participant ID 700064 (Source Sample names: 6888 and 206). We used massively parallel DNA sequencing technologies to screen entire genomes, in an unbiased manner, for genetic changes associated with tumor growth and metastasis. We describe the complete genome sequence ...

phs000245.v1.p1 | EGA
UnknownMutations in Chromatin Modifier and Ephrin Signaling Genes in Vein of Galen Malformation.
Not available
S-EPMC10292091 | biostudies-literature
UnknownMutation of key signaling regulators of cerebrovascular development in vein of Galen malformations.
Not available
S-EPMC10656524 | biostudies-literature
TranscriptomicsInstruction of haematopoietic lineage choices, evolution of transcriptional landscapes and cancer stem cell hierarchies derived from an AML1-ETO mouse model
The t(8;21) chromosomal translocation activates aberrant expression of the AML1-ETO (AE) fusion protein and is commonly associated with core binding factor acute myeloid leukaemia (CBF AML). Combining a conditional mouse model that closely resembles the slow evolution and the mosaic AE expression pa...
ORGANISM(S): Mus musculus 
2013-10-15 | E-MTAB-1820 | biostudies-arrayexpress
ProteomicsSerum integrative omics reveals the landscape of human diabetic kidney disease
Diabetic kidney disease (DKD) is the most common microvascular complication of type 2 diabetes mellitus (2-DM). Currently, urine and kidney biopsy specimens are the major clinical resources for DKD diagnosis. The diagnostic values of blood in monitoring the onset and progression of DKD have not been...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2021-05-22 | MSV000087487 | MassIVE
UnknownSHIP1 therapeutic target enablement: Identification and evaluation of inhibitors for the treatment of late-onset Alzheimer's disease.
Not available
S-EPMC10655782 | biostudies-literature
UnknownDIAPH1 Variants in Non-East Asian Patients With Sporadic Moyamoya Disease.
Not available
S-EPMC8204259 | biostudies-literature
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