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ProteomicsEngineering an orthogonal ubiquitin transfer cascade with Ring E3 RNF38 by phage display to reveal its regulation of nuclear transport
Ring E3 ubiquitin (UB) ligases rely on signature Ring domains for mediating UB transfer to substrate proteins. The large number of Ring E3s and their weak association with substrates pose a significant challenge in identifying the substrates of individual E3s, thereby hindering the elucidation of th...
ORGANISM(S): Homo sapiens (Human) 
2026-08-17 | PXD072090 | Pride
Ubiquitin Ipms rnf38 Mass spectrometry 
ProteomicsEngineering a Cell-Based Orthogonal Ubiquitin Transfer Cascade for Profiling the Substrates of RBR E3 Parkin
The E3 ubiquitin (UB) ligase Parkin utilizes a Ring-Between-Ring (RBR) domain to mediate UB transfer to substrate proteins, and mutations affecting Parkin catalysis promote cancer and are associated with Parkinson’s disease. An essential role of Parkin is to initiate mitophagy by ubiquitinating mito...
ORGANISM(S): Homo sapiens (Human) 
2025-07-28 | PXD063080 | Pride
Ubiquitin Parkin Mass spectrometry E3 
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