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MetabolomicsIon mobility-based sterolomics reveals spatially and temporally distinctive sterol lipids in the mouse brain
Aberrant sterol lipid metabolism is associated with physiological dysfunctions in the aging brain and aging-dependent disorders such as neurodegenerative diseases. There is an unmet demand to comprehensively profile sterol lipids spatially and temporally in different brain regions during aging. Here...
2021-05-24 | MTBLS2457 | MetaboLights
ProteomicsGlobal Profiling of Lysine Accessibility to Evaluate Protein Structure Changes in Alzheimer’s Disease
The linear sequence of amino acids in a protein folds into a 3D structure to execute protein activity and function, but it is still challenging to profile the 3D structure at the proteome scale. Here, we present a method of native protein tandem mass tag (TMT) profiling of Lys accessibility and its ...
ORGANISM(S): Homo sapiens (Human) 
2021-03-23 | PXD024914 | Pride
Structural mass spectrometry Alzheimer’s disease Proteomics Structuromics And tau Tandem mass tag 
ProteomicsSILAC-based quantitative mass spectrometry analysis of RPA1-containing protein complex
SILAC-based quantitative mass spectrometry analysis of RPA1-containing protein complex
ORGANISM(S): Homo Sapiens 
2021-08-25 | PXD028105 |
ProteomicsPorphyromonas gingivalis infection and atherosclerosis
To explore the effect of Porphyromonas gingivalis on lipid-laden macrophages, the project was conduct. Overall design: 8 samples, 4 replicates in 2 groups, with ox-LDL-treated RAW264.7 macrophages stimulated with or without Porphyromonas gingivalis.
ORGANISM(S): Mus Musculus 
2024-01-09 | PXD048371 |
ProteomicsDeep Multilayer Tissue Proteomics Identifies Molecular Networks in Alzheimer’s Disease Progression, human data
The molecular networks underlying Alzheimer’s disease (AD) are not well-defined. We present temporal profiling of >14,000 proteins and >34,000 phosphosites at the asymptomatic and symptomatic stages of AD, deep proteomics analysis of transgenic mouse models.
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2024-10-17 | MSV000096123 | MassIVE
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