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GenomicsGenome-wide maps of H3K27me3 in WT (wild type) and Epi-df (mutant) rice
DNA methylation and histone H3 lysine 9 dimethylation (H3K9me2) are important epigenetic repression marks for silencing transposons in heterochromatin and regulating gene expression in plant development. However, the mechanistic relationship to other repressive marks, such as histone H3 lysine 27 tr...
ORGANISM(S): Oryza sativa 
2013-12-04 | E-GEOD-40674 | biostudies-arrayexpress
TranscriptomicsComparison of transcriptome profile between wild-type and Epi-df mutant plants
We identified and characterized a rice epigenetic mutant Epi-df which exhibits a dwarf stature and various floral defects that are inherited in a dominant fashion. We demonstrated that Epi-df participates in Polycomb repressive complex 2 (PRC2) mediated gene silencing. Epigenetic mutations results i...
ORGANISM(S): Oryza sativa Japonica Group 
2012-07-12 | E-GEOD-39298 | biostudies-arrayexpress
GenomicsDiscrete Functions of Rev-erba Couple Metabolism to the Clock [HTS]
Circadian and metabolic physiology are intricately intertwined, as illustrated by Rev-erb , a transcription factor (TF) that functions both as a core repressive component of the cell autonomous clock and as a regulator of metabolic genes. Here we show that Rev-erb modulates the clock and metabolis...
ORGANISM(S): Mus musculus 
2015-06-16 | E-GEOD-67962 | biostudies-arrayexpress
UnknownPrediction of 6-year mortality in advanced splenomegaly-subtype schistosomiasis: a retrospective cohort study from Hubei, China.
Not available
S-EPMC12927380 | biostudies-literature
TranscriptomicsExpression data of mouse hematopoietic cells, Nr4a1/3 wild type and double mutant
We investigate the cellular and molecular mechanisms of tumor suppression by NR4A1 and NR4A3, and show a cell intrinsic essential function in maintenance of hematopoietic stem cell (HSC) homeostasis. In the absence of Nr4a1/3, HSC lost quiescence, became highly proliferative leukemia-stem cell (LSC)...
ORGANISM(S): Mus musculus 
2013-12-30 | E-GEOD-31042 | biostudies-arrayexpress
TranscriptomicsImpact of library preparation on downstream analysis and interpretation of RNA-seq data: comparison between Illumina PolyA and NuGEN Ovation protocol
Objectives: The sequencing by the PolyA selection is the most common approach for library preparation. With limited amount or degraded RNA, alternative protocols such as the NuGEN have been developed. However, it is not yet clear how the different library preparations affect the downstream analyses ...
ORGANISM(S): Homo sapiens 
2013-08-28 | E-GEOD-47933 | biostudies-arrayexpress
GenomicsMapping ONECUT1 TF binding with ChIP-exo
The aim of this project is to locate the precise binding of the ONECUT1 transcription factor. NOTE: This study was updated on 7th May 2014. All samples, experiments, runs and files were replaced. This was due to an incorrect reagent being used in the earlier version.
ORGANISM(S): Mus musculus 
2014-05-10 | E-MTAB-2060 | biostudies-arrayexpress
ProteomicsProteome and Ubiquitylome Analyses of Maize Endoplasmic Reticulum Under Heat Stress
High temperatures severely affect plant growth and pose a threat to global crop production. Heat causes the accumulation of misfolded proteins in the ER, and triggers the heat shock response (HSR) in the cytosol and the unfolded protein response (UPR) in the ER. Excessive misfolded proteins undergo ...
ORGANISM(S): Zea Mays 
2023-07-24 | PXD044013 |
TranscriptomicsThe G-protein Alpha Subunit Gsα Is A Tumor Suppressor In Sonic Hedgehog-driven Medulloblastoma [Microarray expression]
Medulloblastoma, the most common malignant pediatric brain tumor, is highly heterogeneous with distinct molecular subtypes and cellular origins. Although current treatments improve survival rates, patients suffer severe treatment-related side effects and often relapse of tumors carrying resistance m...
ORGANISM(S): Mus musculus 
2014-08-24 | E-GEOD-60417 | biostudies-arrayexpress
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