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MetabolomicsAkkermansia muciniphila attenuates obsessive-compulsive disorder-like behavior by producing L-tyrosine

Obsessive-compulsive disorder (OCD) ranks among the most prevalent psychiatric disorders globally. The impact of the gut microbiota and associated metabolites on OCD remains unclear. Here, we report a remarkable reduction of Akkermansia muciniphila (A. muciniphila) abundance in both patients and ...

2026-08-20 | MTBLS10145 | MetaboLights
MetabolomicsAkkermansia muciniphila attenuates obsessive-compulsive disorder-like behavior by producing L-tyrosine
Obsessive-compulsive disorder (OCD) ranks among the most prevalent psychiatric disorders globally. The impact of the gut microbiota and associated metabolites on OCD remains unclear. Here, we report a remarkable reduction of Akkermansia muciniphila (A. muciniphila) abundance in both patients and mic...
2026-08-20 | MTBLS10141 | MetaboLights
MetabolomicsExogenous L-Alanine promotes phagocytosis multidrug-resistant bacterial pathogens (L-Alanine-treated macrophage metabolomics)

Multidrug-resistant bacteria present a major threat to public health. Therefore, new drugs or approaches are urgently needed to manage and mitigate this threat. Here, we screen the molecular candidates that allow the survival of mice upon Vibrio parahaemolyticus infection by integrated p...

2024-09-26 | MTBLS7986 | MetaboLights
MetabolomicsExogenous L-Alanine promotes phagocytosis multidrug-resistant bacterial pathogens (V. parahaemolyticus-infected spleen metabolomics)

Multidrug-resistant bacteria present a major threat to public health. Therefore, new drugs or approaches are urgently needed to manage and mitigate this threat. Here, we screen the molecular candidates that allow the survival of mice upon Vibrio parahaemolyticus infection by integrated p...

2024-09-26 | MTBLS7996 | MetaboLights
MetabolomicsL-fucose and fucoidan alleviate high-salt diet-promoted acute inflammation

Excessive salt intake is a widespread health issue observed in almost every country around the world. A high salt diet (HSD) has a strong correlation with numerous diseases, including hypertension, chronic kidney disease and autoimmune disorders. However, the mechanisms underlying HSD-promotion o...

2024-02-21 | MTBLS9134 | MetaboLights
TranscriptomicsTranscriptome analysis of probiotic Lactobacillus casei Zhang during fermentation in soymilk
Lactobacillus casei Zhang is a probiotic bacterium isolated from koumiss in Inner Mongolia of China. Gene expression dynamics of L. casei Zhang during growth in soymilk was investigated in attempt to reveal the mechanisms involved in growth stimulation for growing probiotics in. Comparison of differ...
ORGANISM(S): Lactobacillus casei str. Zhang 
2011-12-31 | E-GEOD-23652 | biostudies-arrayexpress
TranscriptomicsEffect of probiotic Lactobacillus casei Zhang on liver gene expression of hypercholesterolemic rats
The hypocholesterolemic effect of probiotics has been observed, but the molecular mechanism of probiotic-host interaction is still obscure. In this study, DNA microarray technology was used to explore the gene expression profile of liver of hypercholesterolemic rats caused by administration of probi...
ORGANISM(S): Rattus norvegicus 
2011-12-31 | E-GEOD-23740 | biostudies-arrayexpress
MetabolomicsMethionine Intervention Induces PD-L1 Expression to Enhance the Immune Checkpoint Therapy Response in MTAP-deleted Osteosarcoma
Osteosarcoma (OS), a malignant bone tumor with limited treatment options, exhibits low sensitivity to immune checkpoint therapy (ICT). Through genomics and transcriptomics analyses, we have identified a subgroup of OS with methylthioadenosine phosphorylase (MTAP) deletion, which contributes to ICT r...
2026-06-09 | MTBLS11985 | MetaboLights
TranscriptomicsTranscriptomic profiling of L-rhamnose utilization in Lmo0753 deletion mutant of Listeria monocytogenes EGDe from human foodborne outbreak associated lineage LII
Among the three major genetic lineages of L. monocytogenes (i.e. LI, LII, and LIII), LI and LII are predominantly associated with foodborne listeriosis outbreaks, whereas LIII is rarely implicated in human infections. In a previous study, we identified a Crp/Fnr family transcription factor lmo0753 t...
ORGANISM(S): Listeria monocytogenes 
2013-07-17 | E-GEOD-47721 | biostudies-arrayexpress
MetabolomicsElectroacupuncture at Ll11 and SP10 is associated with alleviation of acute urticaria-like reactions in passive cutaneous anaphylaxis: an exploratory analysis of complement-related proteins and multiscale omics

Background: The lifetime prevalence of acute urticaria is approximately 20%. Although electroacupuncture (EA) has been investigated as an adjunctive treatment for urticaria, the molecular mechanisms underlying these effects remain elusive. Passive cutaneous anaphylaxis (PCA) serves as an experime...

2026-06-03 | MTBLS14327 | MetaboLights
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