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ProteomicsDysregulation of N-glycosylation by Rpn1 knockout in spermatocytes induces male infertility via endoplasmic reticulum stress in mice
N-glycosylation protein modification plays a crucial regulatory role in numerous biological processes, although their contribution to male reproduction in mammals remains largely undefined. Here, we found that Ribophorin I (RPN1), a subunit of oligosaccharyltransferase complex, is indispensable for ...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-07 | PXD056290 | Pride
Rpn1  n-glycosylation  meiosis  endoplasmic reticulum stress  fertility 
ProteomicsDysregulation of N-glycosylation by RPN1 knockout in spermatocytes induces male infertility via impaired mitochondrial function in mice
N-glycosylation protein modifications play a crucial regulatory role in numerous biological processes, although their contribution to male reproduction in mammals remains largely undefined. Here, we found that Ribophorin I (RPN1), a subunit of oligosaccharyltransferase complex, is indispensable for ...
ORGANISM(S): Mus musculus (Mouse) 
2025-05-06 | PXD051379 | Pride
Rpn1  n-glycosylation  meiosis  spermatogenesis  fertility 
MetabolomicsMulti-omics Analysis Reveals Multiple Metabolic Processes, Phytohormone Signaling, and the Negative Regulatory Role of ZmPP2CA11 in Maize Seedling Water-Deficit Responses

In this study, the physiological phenotyping, RNA sequencing, widely targeted metabolomics, and phytohormone profiling were used to examine the responses of maize seedlings to progressive PEG-induced osmotic stress and their recovery after PEG removal. 

2026-09-26 | MTBLS15230 | MetaboLights
UnknownMLL-AF9 regulates transcriptional initiation in mixed lineage leukemic cells.
Not available
S-EPMC11345648 | biostudies-literature
TranscriptomicsExpression profiles of IAA biosynthesis deficient seedlings of Arabidopsis thaliana
To gain more information about the Kyn inhibition of TAA1/TARs, we conducted a RNA-seq analysis to compare the genome-wide gene expression profiles of WT seedlings grown on MS medium or MS plus Kyn, and wei8-/- tar2+/- progeny grown on MS. We report that Kyn treatment largely mimics the loss of TAA1...
ORGANISM(S): Arabidopsis thaliana 
2014-12-21 | E-GEOD-32202 | biostudies-arrayexpress
ProteomicsEIF5A couples translational control with transcriptional reprogramming through chromocenter reorganization during spermiogenesis
Translation initiation factor eIF5A facilitates protein synthesis and impacts diverse biological processes, yet its role in transcriptional regulation is poorly understood. Here we find eIF5A highly expressed in diverse spermatogenic cell types. Conditional knockout of Eif5a (SKO) causes complete in...
ORGANISM(S): Mus Musculus 
2025-08-12 | PXD067244 |
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