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Immunotherapy has emerged as a first-line treatment for patients with advanced non-small cell lung cancer (NSCLC), but over half of patients fail to benefit, largely due to tumor heterogeneity and a complex tumor microenvironment. Here, we demonstrate that fibrinogen-like protein 1 (FGL1), a recentl...
ORGANISM(S): Homo Sapiens 
2026-03-27 | PXD076230 |
Spondyloarthritis is a prevalent and persistent condition that significantly impacts the quality of life. Its intricate pathological mechanisms have led to a scarcity of animal models capable of replicating the disease progression in humans, making it a prominent area of research interests in the fi...
ORGANISM(S): Macaca Fascicularis Fascicularis 
2024-05-10 | PXD052158 |

Paraoxonase-1 (PON1) is specifically expressed in the liver and has crucial effects on various liver diseases. The functions and mechanisms underlying of PON1 in hepatocellular carcinoma (HCC) remain obscure. Here, we show that PON1 acts as a metabolic regulator to mitigate regulatory T (Treg) ce...

2025-09-07 | MTBLS12950 | MetaboLights
C-terminal HA tagged hIL-33 were ectopically expressed in HEK293T cells for 24 hours, and demonstrated with indicating stimulations (Ctrl: without stimulations, Pap: 10ug/mL papain exposure for 30min, AS: 0.5mM arsenite exposure for 1hour). Cell lysates were collected for HA-immunoprecipitation and ...
ORGANISM(S): Homo Sapiens 
2022-04-26 | PXD033460 |
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