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Transcriptomicsmedium vs cell miRNA
To investigate the inside and exported miRNA in cell culture system. We characterized the miRNA spectra of cell lines when deprived of serum. The absence of miRNAs present in bovine serum is a distinct advantage of using serum depletion to study extracellular miRNA as it removes potential source of ...
ORGANISM(S): Homo sapiens 
2011-04-23 | E-GEOD-21533 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression profiles of interstitial lung disease (ILD) patients
The mechanisms and molecular pathways underlying interstitial lung diseases (ILDs) are poorly understood. Systems biology approaches were used to identify perturbed networks in these disease states to gain a better understanding of the underlying mechanisms of disease. Through profiling genes and mi...
ORGANISM(S): Homo sapiens 
2011-04-19 | E-GEOD-21394 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of interstitial lung disease (ILD) patients
The mechanisms and molecular pathways underlying interstitial lung diseases (ILDs) are poorly understood. Systems biology approaches were used to identify perturbed networks in these disease states to gain a better understanding of the underlying mechanisms of disease. Through profiling genes and mi...
ORGANISM(S): Homo sapiens 
2011-03-24 | E-GEOD-21369 | biostudies-arrayexpress
TranscriptomicsGene expression networks in COPD: microRNA and mRNA regulation
70 miRNAs and 2667 mRNAs were differentially expressed between lung tissue from subjects with COPD and smokers without COPD. miRNA and mRNA expression profiles enriched for biological pathways that may be relevant to the pathogenesis of COPD including the transforming growth factor b, Wnt and focal ...
ORGANISM(S): Homo sapiens 
2012-06-26 | E-GEOD-38974 | biostudies-arrayexpress
TranscriptomicsThe genetics of splicing in neuroblastoma
Regulation of mRNA splicing is a critical and tightly regulated cellular function, underlying the majority of proteomic diversity in our genomes. While disruption of this process is common in disease, the basic genetic complexity of alternative splicing in vivo remains poorly understood. To delinea...
ORGANISM(S): Mus musculus 
2015-04-03 | E-GEOD-55248 | biostudies-arrayexpress
GenomicsNeuroblastoma relapse trio series from the AMC
The majority of neuroblastoma patients have tumors that initially respond to chemotherapy, but a large proportion of patients will experience therapy-resistant relapses. The molecular basis of this aggressive phenotype is unknown. Whole genome sequencing of 23 paired diagnostic and relapsed neurobla...
EGAS00001001183 | EGA
Genomicsena-DATASET-CURIE-LC-04-05-2015-16:47:47:270-89 - samples
Neuroblastoma, a clinically heterogeneous pediatric cancer, is characterized by distinct genomic profiles but few recurrent mutations. As neuroblastoma is expected to have high degree of genetic heterogeneity, study of neuroblastoma's clonal evolution with deep coverage whole-genome sequencing of di...
EGAD00001001356 | EGA
GenomicsInstitut Curie Neuroblastoma Whole Genome Sequencing Diagnosis Relapse
Neuroblastoma, a clinically heterogeneous pediatric cancer, is characterized by distinct genomic profiles but few recurrent mutations. As neuroblastoma is expected to have high degree of genetic heterogeneity, study of neuroblastoma's clonal evolution with deep coverage whole-genome sequencing of di...
EGAS00001001184 | EGA
Genomicsena-DATASET-AMC-11-05-2015-14:58:16:693-185 - samples
The majority of neuroblastoma patients have tumors that initially respond to chemotherapy, but a large proportion of patients will experience therapy-resistant relapses. The molecular basis of this aggressive phenotype is unknown. Whole genome sequencing of 23 paired diagnostic and relapsed neurobla...
EGAD00001001360 | EGA
GenomicsInstitut Curie Neuroblastoma data access Committee
Data Access Committee EGAC00001000319
EGAC00001000319 | EGA
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