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ProteomicsTherapeutic effect and underlying mechanism of cell therapy on cyclophosphamide-induced premature ovarian insufficiency mouse model
An equivalent dosage of human umbilical cord-derived mesenchymal stem cell (HucMSC), adipose tissue-derived mesenchymal stem cell (ADSC), and SVF was orthotopically administered into a cyclophosphamide (CTX)-induced premature ovarian insufficiency (POI) mouse model. The therapeutic impacts were meti...
ORGANISM(S): Homo Sapiens 
PXD064540 |
ProteomicsThe Shigella kinase effector OspG hijacks host ubiquitin signaling to escape septin-cage entrapment
We show by unbiased phosphoproteomics that a major target of OspG is CAND1, a regulatory protein controlling the assembly of cullin-RING ubiquitin ligases (CRLs). CAND1 phosphorylation weakens its interaction with cullins, which is expected to impact a large panel of CRL E3s. Indeed, global ubiquito...
ORGANISM(S): Homo Sapiens 
2024-01-10 | PXD048447 |
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