Zhang X-L XL - OmicsDI

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Unknown (376)
Proteomics (29)
Transcriptomics (26)
Metabolomics (7)
Genomics (3)

Organisms

Schizophyllum commune H4-8 (19)
Mycobacterium tuberculosis SP7 (19)
Salmonella enterica subsp. enterica serovar Typhimurium str. T000240 (19)
Oryza sativa Japonica Group (19)
Rabbit calicivirus (19)
Crotalus durissus terrificus (19)
Eriocheir sinensis (19)
Candidatus Endoriftia persephonae (19)
Mycobacterium tuberculosis SP10 (19)
Mycobacterium tuberculosis SP13 (19)
Cotesia typhae (19)
Mycobacterium tuberculosis SP22 (19)
Cepaea nemoralis (19)
Enterobacter ludwigii (19)
Trichoderma asperellum CBS 433.97 (19)
Corynebacterium diphtheriae bv. mitis str. ISS 3319 (19)
Nakaseomyces glabratus (19)
Olea europaea (19)
Homo sapiens (18)
Mus musculus (5)
Carassius auratus (2)
Bombyx mori (2)
Paralichthys olivaceus (1)
Clostridium botulinum A str. ATCC 3502 (1)
Moniezia expansa (1)
Populus x canadensis (1)
Schizosaccharomyces pombe (1)
Caenorhabditis elegans (1)
Escherichia coli str. K-12 substr. MG1655 (1)
Pyricularia oryzae 70-15 (1)

Repository

biostudies-arrayexpress (29)
pride (19)
iProX (6)
MetaboLights (6)
MassIVE (4)
GNPS (1)

Tissue

Cell culture (7)
Embryonic stem cell (2)
Leaf (2)
Mycelial cord (1)
Pleura (1)
Plant cell (1)
Blood plasma (1)
Fibroblast (1)
Lung (1)
Epithelial cell (1)
Liver (1)
Colon (1)

Disease

Disease free (2)
Lung cancer (1)

Technology Type

Mass Spectrometry (19)
Shotgun proteomics (10)
Mass spectrometry (6)
Bottom-up proteomics (3)
Gel-based experiment (2)
Affinity purification coupled with mass spectrometry proteomics (2)
Chemical cross-linking coupled with mass spectrometry proteomics (2)
All-ion fragmentation (1)

Instrument Platform

Orbitrap Fusion Lumos (4)
Gas Chromatography MS - (2)
Axon GenePix 4000B scanning hardware (1)
Illumina HiSeq 2500 (1)
LTQ Orbitrap XL (1)
LTQ XL (Thermo Scientific) (1)
PTR-MS (1)
Tandem Gas Chromatography MS - positive (1)
5975C Series GC/MSD (Agilent) (1)
Liquid Chromatography MS - (1)
Liquid Chromatography MS - positive - reverse phase (1)

Publication Date

2010 (10)
2013 (7)
2017 (5)
2019 (5)
2021 (5)
2020 (4)
2015 (3)
2026 (3)
2025 (3)
2022 (3)
2018 (3)
2016 (2)
2014 (2)
2012 (2)
2011 (1)
2009 (1)
2008 (1)
2006 (1)
2023 (1)
2024 (1)

CHEBI ID

CHEBI:16521 (2)
CHEBI:22605 (2)
CHEBI:15366 (2)
CHEBI:28757 (2)
CHEBI:6650 (2)
CHEBI:27693 (2)
CHEBI:18012 (2)
CHEBI:15741 (2)
CHEBI:17268 (2)
CHEBI:30769 (2)
CHEBI:17351 (2)
CHEBI:28842 (2)
CHEBI:15756 (2)
CHEBI:140396 (1)
CHEBI:140398 (1)
CHEBI:14040 (1)
CHEBI:88466 (1)
CHEBI:139373 (1)
CHEBI:139369 (1)
CHEBI:35516 (1)
CHEBI:37710 (1)
CHEBI:25897 (1)
CHEBI:52684 (1)
CHEBI:46998 (1)
CHEBI:37621 (1)
CHEBI:49088 (1)
CHEBI:35189 (1)
CHEBI:89632 (1)
CHEBI:167093 (1)
CHEBI:167091 (1)

Metabolite Name

Dihydroxyindole glucuronide (1)
Phenol Sulphate (1)
Indoxyl sulfate (II) (1)
Indoxyl sulfate (I) (1)
AcetylTryptophan (1)
Vanilloylglycine hydroxyphenyllactic acid conjugate (1)
(Hydroxy-methoxyphenyl)lactic acid (II) (Vanillactic acid II) (1)
(Hydroxy-methoxyphenyl)lactic acid (I) (Vanillactic acid I) (1)
Hydroxyhippuric acid (III) (1)
Hydroxyhippuric acid (II) (1)
Hydroxyhippuric acid (I) (1)
Hydroxyphenylpropionic acid (1)
Hydroxycinnamic acid (II) (1)
Hydroxycinnamic acid (I) (1)
Caffeic acid Sulfate (1)
Ferulic acid sulfate (1)
Coumaroylquinic Acid (III) (1)
Coumaroylquinic Acid (II) (1)
Coumaroylquinic Acid (I) (1)
Feruloylquinic acid (II) (1)
Feruloylquinic acid (I) (1)
(Pyro)Catechol sulfate (1)
Dihydroxyphenyl-gamma-valerolactone methyl glucuronide (III) (1)
Dihydroxyphenyl-gamma-valerolactone methyl glucuronide (II) (1)
Dihydroxyphenyl-gamma-valerolactone methyl glucuronide (I) (1)
(Epi)catechin-sulfate (II) (1)
(Epi)catechin-sulfate (I) (1)
Dihydroquercetin sulfate (1)
Phloretin glucuronide (II) (1)
Phloretin glucuronide (I) (1)

Modification

4-tetrahydrothiazine-3-carboxylic acid (1)

Study type

Transcription profiling by array (18)
ChIP-chip by array (3)
RNA-seq of coding RNA (3)
Unknown experiment type (2)
ChIP-seq (2)
Methylation profiling by high throughput sequencing (1)

Release Date

2020 (49)
2021 (46)
2025 (44)
2022 (44)
2023 (31)
2024 (28)
2018 (28)
2019 (25)
2016 (22)
2017 (19)
2015 (16)
2013 (11)
2010 (11)
2014 (9)
2011 (6)
2026 (6)
2012 (4)
2009 (3)
2008 (1)
2006 (1)
2000 (1)

Lab affiliation

school of life sciences (1)
Lab of Stem cells adn noncoding RNAs, Institue of Molecular Medicine, Peking University (1)
Key Laboratory of Separation Sciences for Analytical Chemistry, National Chromatographic R&A Center, Dalian Institute of Chemical Physics, Chinese Academy of Sciences (CAS), Dalian 116023, Liaoning, P. R. China. (1)
Institute of Model Animal of Wuhan University, Wuhan, China. (1)
Department of Physiology & Biophysics, University of California, Irvine, Irvine, California, USA (1)
Department of Pharmacodynamics, University of Florida (1)
Department of Molecular, Cellular, and Developmental Biology Yale University (1)
Key Laboratory of Genetics and Biotechnology, College of Life Science, Capital Normal University, XisanhuanBeilu No. 105, 100048 Beijing, P. R. of China. (1)
State Key Laboratory of Microbial Metabolism, Joint International Research Laboratory of Metabolic & Developmental Sciences, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai, 200240, China (1)
College of Life Science, Capital Normal University, Beijing 100048, China (1)
Center for Metabolic Disease Research (CMDR) Lewis Katz School of Medicine at Temple University Medical Education and Research Building, Room 1060 3500 N. Broad Street Philadelphia, PA 19140, USA (1)
Faculty of Medicine, University of Ottawa (1)
Huazhong Agricultural University (1)
Center for Proteomics and Metabolomics St. Jude Children's Research Hospital (1)
Institute of Biophysics, Chinese Academy of Sciences (1)
Huazhong University of Science and Technology (1)
THORACIC & GI ONCOLOGY BRANCH, NCI, NIH, Bethesda, MD 20892 (1)
State Key Laboratory of Genetic Engineering, Department of Biochemistry, School of Life Sciences, Fudan University, Shanghai 200438, China (1)
Cornell University (1)

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DT2216 is a specific BCL-XL PROTAC

To validate the specificity of DT2216, we used the stable isotope labeling with amino acids in cell culture (SILAC) and liquid chromatography-tandem mass spectrometry (LC-MS/MS)-based proteomics to analyze the changes in proteins in WI-38 normal human diploid fibroblasts after DT2216 and DT2216NC tr...

ORGANISM(S): Homo sapiens (Human)

2019-10-08 | PXD010878 | Pride

Dt2216 bcl-xl protac silac lc-ms/ms

Transcription profiling of human SCLC cell line set 2

RNA expression analysis was performed to compare patterns to sensitivity to BCL2 inhibitors (ABT-263). Overexpression of the prosurvival Bcl-2 family members (Bcl-2, Bcl-xL and Mcl-1) is commonly associated with tumor maintenance, progression and chemoresistance. We previously reported the discover...

ORGANISM(S): Homo sapiens

2008-06-19 | E-GEOD-10841 | biostudies-arrayexpress

Targeting BCL-XL for degradation synergizes with gemcitabine against cholangiocarcinoma.

Not available

S-EPMC12930748 | biostudies-literature

SAR by interligand nuclear overhauser effects (ILOEs) based discovery of acylsulfonamide compounds active against Bcl-x(L) and Mcl-1.

Not available

S-EPMC3165075 | biostudies-literature

Targeting Bcl-xL is a potential therapeutic strategy for extranodal NK/T cell lymphoma.

Not available

S-EPMC10393801 | biostudies-literature

Anti-apoptotic protein BCL-XL as a therapeutic vulnerability in gastric cancer.