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ProteomicsAnticancer effect of deuterium depleted water - comprehensive proteomics analysis suggests a redox disbalance mechanism
The proteomics data is derived from 4 parts of samples prepared and analysed by nanoLC-MS/MS. In order to make appropriate statistical analysed could be performed, all treatments were performed in biological replicates. The number of replicates was 4 for protein abundances analysis (part 1), 2 for t...
ORGANISM(S): Homo sapiens (Human) 
2019-09-26 | PXD011085 | Pride
Anticancer Proteomics Redox disbalance Deuterium depleted water 
ProteomicsSlight deuterium enrichment in water acts as an antioxidant: is deuterium a cell growth regulator?
Small admixtures in water, e.g. of metal ions, often act as cell growth regulators. Here we report that enrichment of deuterium content in water, normally found at 8 mM concentration, two-three folds increases cell proliferation and lowers the oxidative stress level as well. Acting as an anti-oxidan...
ORGANISM(S): Homo sapiens (Human) 
2020-08-10 | PXD018216 | Pride
Cell growth regulator Antioxidant Deuterium-enriched water Oxidantion-reduction balance 
ProteomicsHigH-ratiO partiaL proteolysiS with carriER proteome (HOLSER) Enables Global Structure Profiling and Site-resolved Elucidation of Ligand-Protein Interactions
Understanding how cellular proteins interact with their environment, including endogenous and exogeneous molecules, is critical for elucidating mechanisms of cellular regulation and drug action. Partial proteolysis-based techniques offer peptide-level resolution of ligand-induced conformational chan...
ORGANISM(S): Homo sapiens (Human) 
2026-09-14 | PXD077592 | Pride
Proteomics Ligand-protein interaction Partial proteolysis Lc-ms-ms 
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