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UnknownBushen Yijing Fang Reduces Fall Risk in Late Postmenopausal Women with Osteopenia: A Randomized Double-blind and Placebo-controlled Trial.
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S-EPMC6375933 | biostudies-literature
TranscriptomicsArabidopsis Flower and Embryo Developmental Genes are Repressed in Seedlings by Different Combinations of Polycomb Group Proteins in Association with Distinct Sets of Cis-regulatory Elements
Polycomb Group Proteins (PcGs) is critical in defining the epigenetic blueprint for animal and plant development. In plants, loss of different PcGs display both common and unique phenotypic defects, yet little is known about how these are established. Here, based on quantitative comparison of epig...
ORGANISM(S): Arabidopsis thaliana 
2016-01-19 | E-GEOD-67322 | biostudies-arrayexpress
TranscriptomicsMNase-seq analysis of Col-0 and chr11-1 chr17-1
Chromatin has a highly organized structure with the repeating nucleosome subunits. The position of nucleosomes on the chromatin is dynamically regulated by ATP-dependent chromatin remodeling factors (remodelers), therefore providing specific epigenetic information. However, the in vivo nucleosome di...
ORGANISM(S): Arabidopsis thaliana 
2014-03-30 | E-GEOD-50242 | biostudies-arrayexpress
GenomicsDynamic, sex-differential STAT5 and BCL6 binding to sex-biased, growth hormone-regulated genes in adult mouse liver
Sex-dependent pituitary growth hormone (GH) secretory patterns determine the sex-biased expression of >1,000 genes in mouse and rat liver, affecting lipid and drug metabolism, inflammation and disease. A fundamental biological question is how robust differential expression can be achieved for hundre...
ORGANISM(S): Mus musculus 
2011-12-18 | E-GEOD-31578 | biostudies-arrayexpress
TranscriptomicsImpact of Cux2 overexpression on gene expression in male and female mouse liver (Mus musculus)
We identified genes expressed in mouse liver that are regulated by Cux2, a highly female-specific liver transcription factor whose expression is regulated by sex-dependent plasma GH patterns. Using adenovirus to overexpress Cux2 (Adeno-Cux2) in male liver, we show that Cux2 represses ~35% of male-b...
ORGANISM(S): Mus musculus 
2012-09-10 | E-GEOD-35897 | biostudies-arrayexpress
GenomicsIdentification of Cux2 binding sites in female and male mouse liver
Growth hormone (GH)-regulated transcription factors, notably STAT5 and BCL6, play a major role in regulating genes showing sex differences in expression in mouse liver, primarily through their effects in male liver, where male-biased genes are up regulated and many female-biased genes are actively r...
ORGANISM(S): Mus musculus 
2012-09-10 | E-GEOD-35985 | biostudies-arrayexpress
TranscriptomicsTranscriptional dysregulation of synaptic genes in a human iPSC model of major mental disorders
Schizophrenia and other psychiatric disorders are postulated to be developmental disorders resulting from synapse dysfunction. How susceptibility genes for major mental disorders could lead to synaptic deficits in humans is not well-understood. Here we generated induced pluripotent stem cells (iPSCs...
ORGANISM(S): Homo sapiens 
2014-08-01 | E-GEOD-57821 | biostudies-arrayexpress
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