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UnknownLiver-Microbiome Crosstalk Mediates the Protective Effects of Artemisinin in Clostridium perfringens Models.
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S-EPMC12569453 | biostudies-literature
TranscriptomicsDNA Methylation Mediated by a MicroRNA Pathway
In plants, the known microRNAs (miRNAs) are produced as ~21 nucleotide (nt) duplexes from their precursors by Dicer like 1 (DCL1). They are incorporated into Argonaute 1 (AGO1) protein to regulate target gene expression primarily through mRNA cleavage. We report here the discovery of a new class of ...
ORGANISM(S): Oryza sativa 
2010-03-12 | E-GEOD-20748 | biostudies-arrayexpress
MetabolomicsHyocholic acid species as novel biomarkers for metabolic disorders
Hyocholic acid (HCA) is a major bile acid (BA) species in the BA pool of pigs, a species known for its exceptional resistance to spontaneous development of diabetic phenotypes. HCA and its derivatives are also present in human blood and urine. We investigate whether human HCA profiles can predict th...
2021-10-06 | MTBLS2343 | MetaboLights
TranscriptomicsGenome-wide maps of AGO1-bound small RNA in Arabidopsis leaves
We report flg22 regulate the accumulation of AGO1-bound small RNA in arabidopsis. We find that a number of miRNAs are up- or down-regulated by flg22, a well-studied PAMP. Examination of AGO1-bound small RNAs with or without flg22 treatment.
ORGANISM(S): Arabidopsis thaliana 
2010-02-25 | E-GEOD-20448 | biostudies-arrayexpress
TranscriptomicsIdentification of small RNAs in rice AGO1 complexes and their targets
This SuperSeries is composed of the following subset Series: GSE18248: Sequencing of rice degradome GSE18250: Profiling of small RNA populations in rice total extract and purified AGO1 complexes Refer to individual Series
ORGANISM(S): Oryza sativa 
2009-11-23 | E-GEOD-18251 | biostudies-arrayexpress
TranscriptomicsSequencing of rice degradome
miRNAs can regulate target gene expression by mRNA cleavage. Rice degradome sequencing was employed to validate mRNA targets of rice miRNAs. Two rice samples, 3-week-old seedling and young panicles were included in the study.
ORGANISM(S): Oryza sativa 
2009-11-23 | E-GEOD-18248 | biostudies-arrayexpress
TranscriptomicsProfiling of small RNA populations in rice total extract and purified AGO1 complexes
microRNAs (miRNAs) are a class of small silencing RNAs that have regulatory roles in gene expression. miRNAs interact with Argonaute (AGO) proteins to form effector complexes that can cleave target mRNAs or repress their translation. Rice encodes four AGO1 homologs (AGO1a, AGO1b, AGO1c, and AGO1d). ...
ORGANISM(S): Oryza sativa 
2009-11-23 | E-GEOD-18250 | biostudies-arrayexpress
MetabolomicsTheabrownin from Pu-erh tea attenuates hypercholesterolemia via modulation of gut microbiota and bile acid metabolism
Pu-erh tea displays cholesterol-lowering properties, but the underlying mechanism has not been elucidated. Theabrownin is one of the most active and abundant pigments in Pu-erh tea. Here, we show that theabrownin alters the gut microbiota in mice and humans, predominantly suppressing microbes associ...
2021-11-18 | MTBLS1259 | MetaboLights
ProteomicsProteomic analysis of patient tissue reveals parallels and discrepancies in immune and mitochondrial processes across mouse models of motor neurone disease
Motor neurone disease (MND) is a fatal neurodegenerative disease resulting in the progressive loss of motor neurons in the brain and spine. More than 95% of cases are pathologically characterized by the cytoplasmic accumulation of hyperphosphorylated and ubiquitinated transactive response DNA-bindin...
ORGANISM(S): Homo sapiens (Human) Mus musculus (Mouse) 
2025-10-06 | PXD062542 | Pride
Motor neurone disease  amyotrophic lateral sclerosis  immune-mediated pathology  mitochondrial dysfunction  neurodegeneration  tdp-43  tmt-proteomics. 
GenomicsAn East-Asian polymorphism underlies BCR-ABL mutation-independent resistance to tyrosine kinase inhibitors in chronic myelogenous leukemia
We used massively parallel DNA sequencing of paired-end ditags (DNA-PET) to identify structural genetic factors associated with disease progression and drug-resistance in representative samples from four CML patients and one CML cell line. The functional consequences of our genetic findings were ev...
ORGANISM(S): Homo sapiens 
2012-02-27 | E-GEOD-28303 | biostudies-arrayexpress
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