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TranscriptomicsGene expression profile of A549 Circulating Tumor Cells from 4D Model.
CTCs in cancer patients are thought to be responsible for metastasis. Currently, there is no ex vivo model that can isolate this group of cells. We have developed an ex vivo 4D lung cancer model that forms perfusable tumor nodules and form CTCs. Gene array analyses show 2504 differentially expressed...
ORGANISM(S): Homo sapiens 
2015-03-12 | E-GEOD-50991 | biostudies-arrayexpress
TranscriptomicsTumor grafts derived from patients with head and neck squamous carcinoma.
Head and neck squamous cell carcinoma (HNSCC) is a deadly and disfiguring disease for which better systemic therapy is desperately needed. The development of new therapies for HNSCC and the understanding of its biology both depend upon clinically relevant animal models. An increasingly promising x...
ORGANISM(S): Homo sapiens 
2013-10-28 | E-GEOD-45153 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of MDA231 cells with alterations involving beta-oxidation pathway
In order to confirm the role of fatty acid β-oxidation in Src regulation, we performed gene expression analysis in MDA231 cells from in vivo model treated with ETX or knockdown of CPT1 or CPT2 using shRNA. As expected, inhibition of β-oxidation showed a gene expression pattern that is opposite to ...
ORGANISM(S): Homo sapiens 
2016-04-14 | E-GEOD-72320 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of transmitochondrial cybrids (triple negative breast cancer cells in SUM159 background)
We used a transmitochondrial cybrid (cybrids)-based discovery approach to identify mitochondria-regulated cancer pathways in TN BCa. Cybrids were generated under a moderately metastatic TN BCa cell line SUM159 as the common nuclear background with mitochondria from benign breast epithelium (A1N4) an...
ORGANISM(S): Homo sapiens 
2016-04-14 | E-GEOD-72319 | biostudies-arrayexpress
TranscriptomicsAblation of Pten and Smad4 leads to metastatic lung carcinoma in a murine model.
Lung cancer is the leading cause of cancer related death in both men and women in the United States. Recently, Smad4 was discovered to be common somatic alteration in human squamous cell lung cancer. Our goal was to delineate the role of Smad4 in lung cancer. We have shown for the first time that t...
ORGANISM(S): Mus musculus 
2015-03-12 | E-GEOD-47116 | biostudies-arrayexpress
TranscriptomicsGene expression profiles of PIK3CA knockdown by shRNA in lung cancer cells
To gain insight into EMT-independent biological processes through which PI3K promotes invasion, RNA samples from 344SQ_p110α shRNA cells and 344SQ_scr cells were subjected to global transcriptional profiling. Two groups, control and PIK3CA shRNA, in 344SQ lung cancer cell line Two group comparison
ORGANISM(S): Mus musculus 
2014-05-02 | E-GEOD-46869 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of histone deacetylase inhibition in epithelioid sarcoma
Epithelioid Sarcoma (ES) is a rare neoplasm uniquely comprised of cells exhibiting both mesenchymal and epithelial features. Having propensity for local and distant recurrence, it can pose a diagnostic dilemma secondary to pathologic complexity. Patients have dismal prognosis due to lack of effectiv...
ORGANISM(S): Homo sapiens 
2015-11-03 | E-GEOD-66800 | biostudies-arrayexpress
TranscriptomicsMicroRNA expression profiling in laryngeal squamous cell carcinoma (LSCC)
In this study, we aimed to explore the role of miR-145, which is downregulated in LSCC, on cancer stem cell potency of laryngeal cancer cells. Using microRNA expression profiling and experimental follow-up studies, we demonstrated the regulatory role of miR-145 in stem cell characteristics of Hep-2 ...
ORGANISM(S): Homo sapiens 
2015-11-10 | E-GEOD-70289 | biostudies-arrayexpress
TranscriptomicsGene expression profiling of metastatic lung cancer cell lines
During malignant disease progression, the extracellular matrix (ECM) of epithelial tumors accumulates inter-molecular cross-links between collagen strands; these cross-links enhance ECM stiffness and trigger tumor cell invasion and dissemination, but the mechanisms that regulate intra-tumoral collag...
ORGANISM(S): Mus musculus 
2015-03-12 | E-GEOD-49315 | biostudies-arrayexpress
GenomicsErbB2 Pathway Activation upon Smad4 Loss Promotes Lung Tumor Growth and Metastasis [ChIP-seq]
Lung cancer remains the leading cause of cancer death. Genome sequencing of lung tumors from patients with Squamous Cell Carcinoma has identified SMAD4 to be frequently mutated. Here we used a novel mouse model to determine the molecular mechanisms regulated by loss of Smad4 which lead to lung cance...
ORGANISM(S): Mus musculus 
2015-03-05 | E-GEOD-57177 | biostudies-arrayexpress
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