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TranscriptomicsLong non-coding RNAs and mRNAs expression analysis of HCC
Although many protein-coding genes have been identified to be aberrantly expressed in hepatocellular carcinoma (HCC), the mechanisms that account for development and progression of HCC remain unclear. In recent years, long noncoding RNAs (lncRNAs) have been shown to have critical regulatory roles in...
ORGANISM(S): Homo sapiens 
2011-09-04 | E-GEOD-27462 | biostudies-arrayexpress
UnknownEfficacy of oral Etoposide in pretreated metastatic breast cancer: a multicenter phase 2 study.
No standard chemotherapy has been defined for metastatic breast cancer (MBC) patients pretreated with anthracyclines and taxanes. A multicenter phase 2 study was conducted to evaluate the safety and efficacy of oral etoposide in patients with MBC.Eligible patients were treated with repeated cycles o...
S-EPMC4603047 | biostudies-literature
UnknownApplications and prospects of cryo-EM in drug discovery.
Drug discovery is a crucial part of human healthcare and has dramatically benefited human lifespan and life quality in recent centuries, however, it is usually time- and effort-consuming. Structural biology has been demonstrated as a powerful tool to accelerate drug development. Among different tech...
S-EPMC9986049 | biostudies-literature
UnknownCoupling of H3K27me3 recognition with transcriptional repression through the BAH-PHD-CPL2 complex in Arabidopsis.
Histone 3 Lys 27 trimethylation (H3K27me3)-mediated epigenetic silencing plays a critical role in multiple biological processes. However, the H3K27me3 recognition and transcriptional repression mechanisms are only partially understood. Here, we report a mechanism for H3K27me3 recognition and transcr...
S-EPMC7718874 | biostudies-literature
UnknownExpression and methylation status of LAMA2 are associated with the invasiveness of nonfunctioning PitNET.
The laminin subunit alpha 2 (LAMA2) gene encodes an alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). In the current study, we investigated the relationship between LAMA2 promoter methylation status and the invasiveness of clinically nonfunctionin...
S-EPMC6351710 | biostudies-literature
UnknownReducing Nav1.6 expression attenuates the pathogenesis of Alzheimer's disease by suppressing BACE1 transcription.
Aberrant increases in neuronal network excitability may contribute to cognitive deficits in Alzheimer's disease (AD). However, the mechanisms underlying hyperexcitability of neurons are not fully understood. Voltage-gated sodium channels (VGSC or Nav), which are involved in the formation of excitabl...
S-EPMC9124306 | biostudies-literature
UnknownJanus effect of FeCo dual atom catalyst with Co as active center in acidic oxygen reduction reaction.
Dual-atom catalysts (DACs) represent a frontier in heterogeneous electrocatalysis for the oxygen reduction reaction (ORR) in proton exchange membrane fuel cells. However, the dynamic evolution of active-site structure complicates mechanistic understanding. Herein, alloyed Fe-Co DACs with strong Fe-C...
S-EPMC12325601 | biostudies-literature
UnknownA chromosome-level genome assembly for the Silkie chicken resolves complete sequences for key chicken metabolic, reproductive, and immunity genes.
A set of high-quality pan-genomes would help identify important genes that are still hidden/incomplete in bird reference genomes. In an attempt to address these issues, we have assembled a de novo chromosome-level reference genome of the Silkie (Gallus gallus domesticus), which is an important avian...
S-EPMC10700341 | biostudies-literature
UnknownSenktide blocks aberrant RTN3 interactome to retard memory decline and tau pathology in social isolated Alzheimer's disease mice.
Sporadic or late-onset Alzheimer's disease (LOAD) accounts for more than 95% of Alzheimer's disease (AD) cases without any family history. Although genome-wide association studies have identified associated risk genes and loci for LOAD, numerous studies suggest that many adverse environmental factor...
S-EPMC10984625 | biostudies-literature
UnknownPrognostic value of systemic inflammation and for patients with colorectal cancer cachexia.

Background

The development and progression of cancer cachexia are connected to systemic inflammation and physical performance. However, few relevant studies have reported the survival outcomes prediction of systemic inflammation and physical performance in patients with colorectal cancer (CR...
S-EPMC10751398 | biostudies-literature
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