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TranscriptomicsHuman PA-1 cells treated with scrambled or specific ASOs
We describe the discovery of sno-lncRNAs, a class of nuclear-enriched intron-derived long noncoding RNAs (lncRNAs) that are processed on both ends by the snoRNA machinery. During exonucleolytic trimming, the sequences between the snoRNAs are not degraded, leading to the accumulation of lncRNAs flank...
ORGANISM(S): Homo sapiens 
2013-04-26 | E-GEOD-38541 | biostudies-arrayexpress
UnknownPromotion of Lung Cancer Metastasis by SIRT2-Mediated Extracellular Protein Deacetylation.
Acetylation of extracellular proteins has been observed in many independent studies where particular attention has been given to the dynamic change of the microenvironmental protein post-translational modifications. While extracellular proteins can be acetylated within the cells prior to their micro...
S-EPMC9875677 | biostudies-literature
UnknownInterleukin-37 promotes DMBA/TPA skin cancer through SIGIRR-mediated inhibition of glycolysis in CD103+DC cells.
Interleukin 37 (IL-37), a member of the IL-1 family, is considered a suppressor of innate and adaptive immunity and, hence is a regulator of tumor immunity. However, the specific molecular mechanism and role of IL-37 in skin cancer remain unclear. Here, we report that IL-37b-transgenic mice (IL-37tg...
S-EPMC9986080 | biostudies-literature
UnknownNeuronal Induction of Bone-Fat Imbalance through Osteocyte Neuropeptide Y.
A differentiation switch of bone marrow mesenchymal stem/stromal cells (BMSCs) from osteoblasts to adipocytes contributes to age- and menopause-associated bone loss and marrow adiposity. Here it is found that osteocytes, the most abundant bone cells, promote adipogenesis and inhibit osteogenesis of ...
S-EPMC8693044 | biostudies-literature
UnknownCoding mutations in NUS1 contribute to Parkinson's disease.
Whole-exome sequencing has been successful in identifying genetic factors contributing to familial or sporadic Parkinson's disease (PD). However, this approach has not been applied to explore the impact of de novo mutations on PD pathogenesis. Here, we sequenced the exomes of 39 early onset patients...
S-EPMC6233099 | biostudies-literature
UnknownExtracellular Vesicles from Child Gut Microbiota Enter into Bone to Preserve Bone Mass and Strength.
Recently, the gut microbiota (GM) has been shown to be a regulator of bone homeostasis and the mechanisms by which GM modulates bone mass are still being investigated. Here, it is found that colonization with GM from children (CGM) but not from the elderly (EGM) prevents decreases in bone mass and b...
S-EPMC8097336 | biostudies-literature
UnknownBiomarkers of aging.
Aging biomarkers are a combination of biological parameters to (i) assess age-related changes, (ii) track the physiological aging process, and (iii) predict the transition into a pathological status. Although a broad spectrum of aging biomarkers has been developed, their potential uses and limitatio...
S-EPMC10115486 | biostudies-literature
UnknownUltrahigh-energy gamma-ray emission associated with black hole-jet systems.
Black holes (BHs), one of the most intriguing objects in the universe, can manifest themselves through electromagnetic radiation initiated by the accretion flow. Some stellar-mass BHs drive relativistic jets when accreting matter from their companion stars, forming microquasars. Non-thermal emission...
S-EPMC12746838 | biostudies-literature
UnknownRobust estimation of bacterial cell count from optical density.
Optical density (OD) is widely used to estimate the density of cells in liquid culture, but cannot be compared between instruments without a standardized calibration protocol and is challenging to relate to actual cell count. We address this with an interlaboratory study comparing three simple, low-...
S-EPMC7499192 | biostudies-literature
UnknownGuidelines for the use and interpretation of assays for monitoring autophagy (3rd edition).
Not available
S-EPMC4835977 | biostudies-literature
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