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TranscriptomicsAtoh1 inhibits neuronal differentiation and collaborates with Gli1 to generate medulloblastoma-initiating cells
The morphogen and mitogen, Sonic Hedgehog, activates a Gli1-dependent transcription program that drives proliferation of granule neuron progenitors (GNPs) within the external germinal layer of the postnatally developing cerebellum. Medulloblastomas with mutations activating the Sonic Hedgehog signa...
ORGANISM(S): Mus musculus 
2010-07-08 | E-GEOD-19684 | biostudies-arrayexpress
ProteomicsComparative proteomic and metabolomic analysis of resistant and susceptible Kentucky Bluegrass cultivars in response to infection by powdery mildew
In this study, we first analyzed the disease incidence of different disease-resistant P. pratensis varieties, and then investigated changes in their in vivo redox states. Isobaric tags for relative and absolute (iTRAQ) proteomics and nontargeted metabolomics were utilized to elucidate the response m...
ORGANISM(S): Poa Pratensis 
2024-05-25 | PXD052577 |
TranscriptomicsIntegrated molecular genetic profiling of pediatric-high grade gliomas reveals key differences with adult disease
Purpose: To define copy number alterations and gene expression signatures underlying pediatric high-grade glioma (HGG). Patients and Methods: We conducted a high-resolution analysis of genomic imbalances in 78 de novo pediatric HGG, including 7 diffuse intrinsic pontine gliomas, and 10 HGG cases ar...
ORGANISM(S): Homo sapiens 
2010-06-15 | E-GEOD-19578 | biostudies-arrayexpress
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