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ProteomicsInsight into the underlying molecular mechanism of dilated cardiomyopathy through integrative analysis of data mining, iTRAQ-PRM proteomics and bioinformatics
DCM is a common cardiomyopathy worldwide, which is characterized by ventricular dilatation and systolic dysfunction. DCM is one of the most common diseases contributing to sudden death and heart failure. However, our understanding of its molecular mechanisms is limited because of its etiology and un...
ORGANISM(S): Rattus norvegicus (Rat) 
2023-10-24 | PXD038946 | Pride
Mechanisms Molecular pathways Gene network Bioinformatics Dilated cardiomyopathy 
ProteomicsColonic smooth-muscle BIN1 and ALDH1B1 loss triggers mitochondrial dysfunction and fibrosis in slow-transit constipation
Slow-transit constipation (STC) is a debilitating disorder of colonic motility with poorly defined molecular underpinnings. While abnormalities in the enteric nervous system and interstitial cells of Cajal have been extensively studied, smooth-muscle–intrinsic mechanisms remain largely unexplored. H...
ORGANISM(S): Homo sapiens (Human) 
2026-09-07 | PXD069723 | Pride
Mitochondrial function  fibrosis  intestinal motility 
TranscriptomicsTracing the transcriptomic changes of synthetic trigenomic allohexaploid in Brassica by RNA-Seq approach
We explored the transcriptomic changes of synthetic Brassica allohexaploid by comparing to its parents using a high-throughput RNA-Seq method. A total of 35644409 sequence reads were generated, and 32642 genes were aligned from the data. There were 29260, 29060 and 29697 genes identified in Brassica...
ORGANISM(S): Brassica carinata x Brassica rapa 
2014-10-10 | E-GEOD-46299 | biostudies-arrayexpress
TranscriptomicsThe Pitx2:miR-200c/141:noggin pathway regulates BMP signaling and ameloblast differentiation
The mouse incisor is a remarkable tooth that grows throughout the animalM-bM-^@M-^Ys lifetime. This continuous renewal is fueled by epithelial stem cells that give rise to ameloblasts, which generate enamel, and little is known about the function of specific miRNAs in this process. Here we describe ...
ORGANISM(S): Mus musculus 
2013-07-09 | E-GEOD-48583 | biostudies-arrayexpress
MetabolomicsThe telomere-to-telomere (T2T) genome of Peucedanum praeruptorum Dunn provides insights into the genome evolution and coumarin biosynthesis

BACKGROUND: Traditional Chinese medicine has used Peucedanum praeruptorum Dunn (Apiaceae) for a long time. Various coumarins, including the significant root constituents Praeruptorin (A-E), are the active constituents of the dried roots of P. praeruptorum. Previous trans...

2024-04-02 | MTBLS8679 | MetaboLights
ProteomicsImmune response pattern across the asymptomatic, symptomatic and convalescent periods of COVID-19
We present an integrated analysis of urine and serum proteomics and clinical measurements in asymptomatic, mild/moderate, severe and convalescent cases of COVID-19. We identify the pattern of variation of immune response proteins during COVID-19 infection. The immune response is activated in asympto...
ORGANISM(S): Homo Sapiens 
PXD026442 |
ProteomicsPeptide codes for organ-selective mRNA delivery
Organ-selective delivery of messenger RNA (mRNA) is critical for fulfilling the therapeutic potential of mRNA-based gene and protein replacement technologies. Despite clinical advances in hepatic delivery of mRNA using lipid nanoparticles (LNPs), strategies for extrahepatic organ-selective mRNA deli...
ORGANISM(S): Mus Musculus 
PXD043932 |
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