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ProteomicsRegulation of the Endocytosis and Prion Chaperoning Machineries by Yeast E3 Ubiquitin Ligase Rsp5 as Revealed by Orthogonal Ubiquitin Transfer
Attachment of the ubiquitin (UB) peptide to proteins via the E1-E2-E3 enzymatic machinery regulates diverse biological pathways, yet identification of the substrates of E3 UB ligases remains a challenge. We overcame this challenge by constructing an “orthogonal UB transfer (OUT) cascade with yeast E...
ORGANISM(S): Saccharomyces cerevisiae (Baker's yeast) 
2022-10-13 | PXD023688 | Pride
Ubiquitin Lc-ms/ms 
UnknownOnline decision tools for personalized survival prediction and treatment optimization in elderly patients with lung squamous cell carcinoma: a retrospective cohort study.
Not available
S-EPMC10542697 | biostudies-literature
TranscriptomicsJnk1 in murine hepatic stellate cells is a crucial mediator of liver fibrogenesis
Hepatic fibrosis is a wound-healing response to chronic liver injury, which may result in cirrhosis and liver failure. The c-Jun N-terminal kinase-1 (JNK1) gene has been shown to be involved in liver fibrosis. Here, we aimed to investigate the molecular mechanism and identify the cell-type involved ...
ORGANISM(S): Mus musculus 
2013-11-27 | E-GEOD-40041 | biostudies-arrayexpress
MetabolomicsExogenous L-Alanine promotes phagocytosis multidrug-resistant bacterial pathogens (V. parahaemolyticus-infected spleen metabolomics)

Multidrug-resistant bacteria present a major threat to public health. Therefore, new drugs or approaches are urgently needed to manage and mitigate this threat. Here, we screen the molecular candidates that allow the survival of mice upon Vibrio parahaemolyticus infection by integrated p...

2024-09-26 | MTBLS7996 | MetaboLights
TranscriptomicsDual function of Jnk1 and Jnk2 in hepatocytes is essential to protect against toxic liver injury
BACKGROUND & AIMS: c-Jun N-terminal kinase (JNK)1 and JNK2 are expressed in hepatocytes and have overlapping and distinct functions. JNK proteins are activated, via phosphorylation, in response to acetaminophen- or CCl4-induced liver damage; the level of activation correlates with the degree of inju...
ORGANISM(S): Mus musculus 
2016-01-04 | E-GEOD-59602 | biostudies-arrayexpress
UnknownJUN mediates glucocorticoid resistance by stabilizing HIF1a in T cell acute lymphoblastic leukemia.
Not available
S-EPMC10661119 | biostudies-literature
Unknownc-Jun N-terminal kinase promotes stem cell phenotype in triple-negative breast cancer through upregulation of Notch1 via activation of c-Jun.
Not available
S-EPMC6116358 | biostudies-literature
UnknownAutoantibodies in Chinese patients with chronic hepatitis B: prevalence and clinical associations.
Not available
S-EPMC4284347 | biostudies-literature
UnknownZFP36, an RNA-binding protein promotes hBMSCs osteogenic differentiation via binding with JUN.
Not available
S-EPMC11562521 | biostudies-literature
UnknownStructural insights into catalysis and dimerization enhanced exonuclease activity of RNase J.
Not available
S-EPMC4477667 | biostudies-literature
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