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MetabolomicsChanges in L-phenylalanine concentration reflect and predict response to anti-PD-1 treatment combined with chemotherapy in patients with non-small cell lung cancer
Chemotherapy combined with checkpoint blockade antibodies targeting programmed cell death protein (PD-1) has achieved remarkable success in non-small cell lung cancer (NSCLC). However, few patients benefit from long-term treatment. Therefore, biomarkers capable of guiding the optimal therapeutic sel...
2025-06-16 | MTBLS11232 | MetaboLights
TranscriptomicsExpression data from murine colon tissue after exposure to 4% DSS for 6 days DSS followed by 4 days of water or 1% L-arginine
L-Arginine (L-Arg) is the substrate for both inducible nitric oxide synthase and arginase, which are upregulated in human IBD and in mouse colitis models. We have found that L-Arg supplementation enhances wound restitution in vitro, and improves the clinical parameters of weight loss, survival, and ...
ORGANISM(S): Mus musculus 
2012-06-26 | E-GEOD-34874 | biostudies-arrayexpress
TranscriptomicsMapping of INS promoter interactions reveals its role in long-range regulation of SYT8 transcription
Insulin (INS) synthesis and secretion from pancreatic M-NM-2 cells are tightly regulated; their deregulation causes diabetes. Here we map INS-associated loci in human pancreatic islets by 4C and 3C techniques and show that the INS gene physically interacts with the SYT8 gene, located over 300 kb ...
ORGANISM(S): Homo sapiens 
2011-02-22 | E-GEOD-25862 | biostudies-arrayexpress
ProteomicsEffects of arbuscular mycorrhizal fungi on Pteris cretica L var. nervosa fronds antimony enrichment, morphology and proteome changes during antimony phytoremediation
Pteris cretica L var. nervosa is one of the dominent fern species at antimony mining area where arbuscular mycorrhizal fungi can be found as a symbiosis. The effect of AMF on fern exposed to long-term excessive Sb was pooly understood. The project applied this fern co-cultivting with or withour AMF ...
ORGANISM(S): Pteris cretica var. nervosa 
2024-01-19 | PXD012678 | Pride
Arbuscular mycorrhizal fungi Antimony phytoremediation Pteris cretica l var. nervosa Long-term exposure Fronds proteomic identification 
ProteomicsLong-term exposure to biodegradable polylactic acid microplastics promotes Microcystis aeruginosa proliferation
Biodegradable plastics, such as polylactic acid (PLA), are widely considered as sustainable alternatives to fossil fuel-derived polymers; however, their degradation generates polylactic acid microplastics (PLA-MPs), which raises ecological concerns in freshwater ecosystems. In this study, we investi...
ORGANISM(S): Microcystis Aeruginosa 
PXD069473 |
TranscriptomicsEffect of in vitro transcription time on the fidelity of T7-based RNA linear amplification
Zhao et al. Amplification Figure 1 This experiment was designed to evaluate the effect of in vitro transcription time on the fidelity, reproducibility, and yield of T7 based linear amplification. Duplicate reactions were performed at 37 degree for 2, 3, 4, 5, and 6 hours. Two additional 5-hour incub...
ORGANISM(S): Homo sapiens 
2005-11-03 | E-GEOD-3558 | biostudies-arrayexpress
UnknownAssociation of IL-17 polymorphisms with gastric cancer risk in Asian populations.
Not available
S-EPMC4427697 | biostudies-literature
TranscriptomicsAsthma III
Bronchial Epithelial Cells were isolated processed as described (Chu et al., 2002 and Zhao et al., 2011). The objective of the study was to identify differentially expressed genes between normal control (NC), mild-moderate asmathic (notSA) and severe asthmatic (SA) patients. For demographics data,...
ORGANISM(S): Homo sapiens 
2015-10-27 | E-GEOD-67940 | biostudies-arrayexpress
UnknownFunctional Characterization of a Drought-Responsive Invertase Inhibitor from Maize (Zea mays L.).
Not available
S-EPMC6747265 | biostudies-literature
UnknownMetastasis-associated long noncoding RNAs in gastrointestinal cancer: Implications for novel biomarkers and therapeutic targets.
Not available
S-EPMC5075548 | biostudies-literature
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