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TranscriptomicsApc restoration promotes cellular differentiation and reestablishes crypt homeostasis in colorectal cancer
The Adenomatous Polyposis Coli (APC) tumor suppressor is mutated in the vast majority of human colorectal cancers (CRC) and leads to deregulated Wnt signaling. To determine whether Apc disruption is required for tumor maintenance, we developed a mouse model of CRC whereby Apc can be conditionally su...
ORGANISM(S): Mus musculus 
2015-06-18 | E-GEOD-67186 | biostudies-arrayexpress
UnknownImmune and genomic correlates of response to anti-PD-1 immunotherapy in glioblastoma.
Not available
S-EPMC6810613 | biostudies-literature
Proteomics,MultiomicsCyclin C-CDK3/8/19 kinases play a tumor-suppressive role in vivo
Cyclin C was cloned as a growth-promoting G1 cyclin1,2, and several studies postulated a role for cyclin C in driving cell proliferation3-8 . Moreover, cyclin C, together with its kinase partner, the cyclin-dependent kinase CDK8, is believed to represent an essential component of basal transcrip...
ORGANISM(S): Homo Sapiens (ncbitaxon:9606) 
2017-03-29 | MSV000080728 | MassIVE
UnknownAdvanced Age in Humans and Mouse Models of Glioblastoma Show Decreased Survival from Extratumoral Influence.
Not available
S-EPMC10690140 | biostudies-literature
UnknownERK1/2 phosphorylation predicts survival following anti-PD-1 immunotherapy in recurrent glioblastoma.
Not available
S-EPMC8818262 | biostudies-literature
ProteomicsTumor and adjacent normal tissue
Proteome characterization of 5 breast tumors and adjacent normal tissue using HiRIEF nanoLC-MS/MS.
ORGANISM(S): Homo Sapiens (human) 
2019-02-04 | PXD011385 | JPOST Repository
ProteomicsBreast cancer proteome landscape
Proteome characterization of 45 breast tumors using HiRIEF nanoLC-MS/MS.
ORGANISM(S): Homo Sapiens (human) 
2019-02-04 | PXD008841 | JPOST Repository
UnknownA benchmark of expert-level academic questions to assess AI capabilities.
Not available
S-EPMC12851929 | biostudies-literature
UnknownUsing CSF biomarkers to replicate genetic associations in Alzheimer's disease.
Not available
S-EPMC3150628 | biostudies-literature
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