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MetabolomicsLow chorionic villous succinate accumulation associates with recurrent spontaneous abortion risk
Dysregulated extravillous trophoblast invasion and proliferation are known to increase the risk of recurrent spontaneous abortion (RSA); however, the underlying mechanism remains unclear. Herein, in our retrospective observational case-control study we show that villous samples from RSA patients, co...
2021-10-06 | MTBLS2148 | MetaboLights
ProteomicsPhenylalanine Impairs Insulin Signaling and Inhibits Glucose Uptake Through Modification of IRβ
Whether amino acids act on cellular insulin signaling remains unclear, given that increased circulating amino acid levels are associated with the onset of type 2 diabetes (T2D). Here, we report that phenylalanine modifies insulin receptor beta (IRβ) and inactivates insulin signaling and glucose upta...
ORGANISM(S): Homo sapiens (Human) 
2022-07-22 | PXD035076 | Pride
Type 2 diabetes Phenylalanylation Insulin receptor 
UnknownStructural basis for Gemin5 decamer-mediated mRNA binding.
Not available
S-EPMC9440017 | biostudies-literature
GenomicsGenome wide association study of leprosy in Chinese population

Leprosy is a chronic infectious disease caused by Mycobacterium leprae (M. leprae). Due to M. leprae's narrow host range and an inability to be cultured in vitro, the biological investigation of this disease has been difficult. Host genetic factors have been ...

phs000217.v1.p1 | EGA
UnknownThe sequence and de novo assembly of the giant panda genome.
Not available
S-EPMC3951497 | biostudies-literature
UnknownExtracting the femtometer structure of strange baryons using the vacuum polarization effect.
Not available
S-EPMC11470094 | biostudies-literature
UnknownUltrahigh-energy gamma-ray emission associated with black hole-jet systems.
Not available
S-EPMC12746838 | biostudies-literature
UnknownPrognostic evaluation of quick sequential organ failure assessment score in ICU patients with sepsis across different income settings.
Not available
S-EPMC10804657 | biostudies-literature
UnknownSex-stratified genome-wide association studies including 270,000 individuals show sexual dimorphism in genetic loci for anthropometric traits.
Not available
S-EPMC3674993 | biostudies-literature
UnknownGenome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture.
Not available
S-EPMC3973018 | biostudies-literature
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