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TranscriptomicsThe peroxisome proliferator-activated receptor-gamma agonist pioglitazone modulates aberrant T cell responses in systemic lupus erythematosus
Previous studies indicate that peroxisome proliferator-activated receptor-gamma (PPAR-g) agonists suppress autoimmune responses and renal inflammation in murine lupus. However, the mechanisms implicated in this process remain unclear. We tested the effect of the PPAR-g agonist pioglitazone in human ...
ORGANISM(S): Homo sapiens 
2014-12-08 | E-GEOD-45923 | biostudies-arrayexpress
TranscriptomicsHuman lupus netting neutrophils induce endothelial damage, infiltrate tissues and expose immunostimulatory molecules
Our group has proposed that low-density granulocytes (LDGs) play an important role in lupus pathogenesis, as they can damage endothelial cells and synthesize increased levels of proinflammatory cytokines and type I interferons. LDGs have a heightened capacity to synthesize neutrophil extracellular t...
ORGANISM(S): Homo sapiens 
2011-06-22 | E-GEOD-26975 | biostudies-arrayexpress
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