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ProteomicsExploration of the antioxidant effect of spermidine on the ovary and screening and identification of differentially expressed proteins
Spermidine is a naturally occurring polyamine compound that has many biological functions, such as inducing autophagy and anti-inflammatory and anti-aging effects. In this study, ICR mice were fed exogenous spermidine drinking water for three months to explore the regulation of ovarian function by s...
ORGANISM(S): Mus Musculus 
2022-12-12 | PXD038755 |
ProteomicsProteomics of obstructed kidneys from patients with obstructive nephropathy and unilateral ureteral obstruction mice
Here, we performed proteomics of kidneys obtained from patients with obstructive nephropathy and healthy controls (n=11/8), or from unilateral ureteral obstruction (UUO) mice and sham mice (n=6/6). Proteomic measurement of all human kidney samples resulted in a total of 6089 proteins with an average...
ORGANISM(S): Homo Sapiens Mus Musculus 
2023-01-08 | PXD039314 |
ProteomicsBRAF inhibitors enhance erythropoiesis and treat anemia through paradoxical activation of MAPK
Erythropoiesis is a crucial part in hematopoietic system, while facing disruptions from various diseases conditions. Anemia and blood shortages has become global challenges, with current finite pharmacological options like EPO or glucocorticoids having limitations, especially in genetic anemias like...
ORGANISM(S): Homo Sapiens 
2024-09-09 | PXD055730 |
TranscriptomicsCritical Role of Sphingolipid Pathway Components in Murine Radiation-Induced Lung Injury: Protection by Sphingosine-1-Phosphate Analogues
Clinically significant radiation-induced lung injury (RILI) is associated with significant morbidity and mortality and a common toxicity in patients administered thoracic radiotherapy. While the molecular etiology of RILI is poorly understood, we previously characterized a murine model of RILI in wh...
ORGANISM(S): Mus musculus 
2010-11-17 | E-GEOD-25295 | biostudies-arrayexpress
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