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MetabolomicsLipid-accumulated reactive astrocytes promote disease progression in epilepsy (Human lipidomics)

Reactive astrocytes play an important role in neurological diseases, but their molecular and functional phenotypes in epilepsy are unclear. Here, we show that in patients with temporal lobe epilepsy (TLE) and mouse models of epilepsy, excessive lipid accumulation in astrocytes leads to the format...

2025-07-03 | MTBLS8856 | MetaboLights
MetabolomicsLipid-accumulated reactive astrocytes promote disease progression in epilepsy (Mice lipidomics)

Reactive astrocytes play an important role in neurological diseases, but their molecular and functional phenotypes in epilepsy are unclear. Here, we show that in patients with temporal lobe epilepsy (TLE) and mouse models of epilepsy, excessive lipid accumulation in astrocytes leads to the format...

2025-07-04 | MTBLS8865 | MetaboLights
TranscriptomicsReal-time quantitative PCR analysis of DZNep treated B cell Lymphoma cell line Jeko-1
Jeko-1 cells were culture with or without PRC2 inhibitor 3-deazaneplanocin A (DZNep)(1uM) for 72hrs. We used TaqManM-BM-. Human MicroRNA Array to quantitate miRNA expression profile regulated by PRC2. qPCR miRNA expression profiling.
ORGANISM(S): Homo sapiens 
2012-08-11 | E-GEOD-40019 | biostudies-arrayexpress
ProteomicsHuman Plasma Proteome with Three-dimensional Strategies by Highresolution Quadrupole Orbitrap Mass Spectrometry
Five three-dimensional strategies combining HAP depletion (the 1st dimension) and protein fractionation (the 2nd dimension), followed by LC-MS/MS analysis (the 3rd dimension) were developed and compared for human plasma proteome profiling. Pros and cons of the five strategies are discussed for two i...
ORGANISM(S): Homo Sapiens 
2017-06-20 | PXD008441 |
ProteomicsCell type resolved liver proteomics
Parenchymatous organs consist of multiple cell types, primarily defined as parenchymal cells (PCs) and nonparenchymal cells (NPCs). The cellular characteristics of these organs are not well understood. Proteomic studies facilitate the resolution of the molecular details of different cell types in or...
ORGANISM(S): Mus Musculus 
2017-04-20 | PXD008430 |
ProteomicsProteomics comparison of protein changes in H1299 cell before and after resistance to cdk4/6 inhibitors
This is the raw proteomics data of H1299 cell before and after resistance to cdk4/6 inhibitors
ORGANISM(S): Homo Sapiens 
2023-05-15 | PXD042216 |
TranscriptomicsComparison of gene expression profiling of human lung at four developmental stages and lung adenocarcioma
It is gradually becoming a new aspect in research to search and explore embryo development for malignant information hidden in tumor cells. In this study, the gene expression profiles for human lungs at four developmental stages and lung adenocarcinoma (ADC) were depicted, respectively. The molecula...
ORGANISM(S): Homo sapiens 
2014-08-25 | E-GEOD-43767 | biostudies-arrayexpress
ProteomicsAn Orthogonal Extraction Workflow for High-Depth Plasma Proteomics with Metabolomic Compatibility from Low Microliter-Scale Samples
Herein, we report an orthogonal extraction workflow that achieves enhanced proteomic profiling depth while preserving metabolomic compatibility from a mere 10 µL of plasma. We demonstrate that a ternary solvent mixture (TSM) of methanol, acetonitrile, and acetone exhibits distinct chemical orthogona...
ORGANISM(S): Homo Sapiens 
2026-02-03 | PXD073964 |
ProteomicsThe MS data for precision evaluation of absolute quantification algorithms
Human embryonic kidney (HEK) cells 293 are analyzed by two state-of-the-art MS instruments (Thermo Orbitrap Fusion and Q Exactive HF) in quadruplicate for precision evaluation.
ORGANISM(S): Homo Sapiens 
2018-05-08 | PXD009720 |
ProteomicsThe MS data for accuracy evaluation of absolute quantification algorithms
The DDA and DIA data for accuracy evaluation of absolute quantification algorithms.
ORGANISM(S): Mus Musculus Saccharomyces Cerevisiae 
2018-05-08 | PXD009719 |
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