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TranscriptomicsGenetic stability and germ cell epigenetic instability in the Mtrr mouse model of transgenerational epigenetic inheritance.
Folate metabolism is important for DNA synthesis and repair through its role in the synthesis of the nucleotide thymidine. Mice with a hypomorphic mutation in the gene Mtrr have disrupted folate metabolism and show transgenerational inheritance of developmental abnormalities. We sought to explore if...
ORGANISM(S): Mus musculus 
2021-04-06 | E-MTAB-8513 | biostudies-arrayexpress
TranscriptomicsMouse Marginal Zone B-cell with/without Tfh RNASeq data analysis
Mouse Marginal Zone B-cell with/without Tfh
ORGANISM(S): Mus musculus 
2024-01-24 | E-MTAB-11677 | biostudies-arrayexpress
TranscriptomicsIdentifying crossover locations in Arabidopsis thaliana CMT3-11 (Col) x CMT3-7 (Ler) F2 and wild type Col x Ler F2 populations using genotyping by sequencing
Genomic DNA from 384 CMT3-11 (Col) x CMT3-7 (Ler) F2 and 171 wild type Col x Ler F2 individuals was extracted using CTAB and used to generate sequencing libraries as described (Rowan et al; Yelina et al), with the following modifications. DNA was extracted from 3 rosette leaves of 5 week old plants ...
ORGANISM(S): Arabidopsis thaliana 
2017-06-05 | E-MTAB-5476 | biostudies-arrayexpress
TranscriptomicsGerm cell epigenetic instability in the Mtrr mouse model of transgenerational epigenetic inheritance
Folate metabolism is important for the generation of methyl groups required for cellular methylation reactions. Mice with a hypomorphic mutation in the gene Mtrr have disrupted folate metabolism and show transgenerational inheritance of developmental abnormalities. We sought to explore if DNA methyl...
ORGANISM(S): Mus musculus 
2021-04-06 | E-MTAB-8533 | biostudies-arrayexpress
TranscriptomicsIdentifying crossover locations in Arabidopsis thaliana recq4a recq4b and HEI10 recq4a recq4b Col x Ler F2 populations using genotyping by sequencing
Genomic DNA from 192 recq4a recq4b and 192 HEI10 recq4a recq4b Col x Ler F2 individuals was extracted using CTAB and used to generate sequencing libraries as described (Ziolkowski et al, 2017 Genes & Dev). Sequencing data was analysed to identify crossovers as previously reported, using the TIGER pi...
ORGANISM(S): Arabidopsis thaliana 
2017-11-30 | E-MTAB-5949 | biostudies-arrayexpress
TranscriptomicsIdentifying crossover locations in Arabidopsis thaliana wild-type Col x Ler F2 populations using genotyping by sequencing
Genomic DNA from 74 wild type Col x Ler F2 individuals was extracted using CTAB and used to generate sequencing libraries as described (Rowan et al; Yelina et al), with the following modifications. DNA was extracted from 3 rosette leaves of 5 week old plants and 150 ng of DNA used as input for each ...
ORGANISM(S): Arabidopsis thaliana 
2018-03-17 | E-MTAB-6577 | biostudies-arrayexpress
MetabolomicsHyocholic acid species as novel biomarkers for metabolic disorders
Hyocholic acid (HCA) is a major bile acid (BA) species in the BA pool of pigs, a species known for its exceptional resistance to spontaneous development of diabetic phenotypes. HCA and its derivatives are also present in human blood and urine. We investigate whether human HCA profiles can predict th...
2021-10-06 | MTBLS2343 | MetaboLights
TranscriptomicsThyroid deficiency before birth modifies adipose transcriptome to promote overgrowth of white adipose tissue and impair thermogenic capacity
This study investigates the development of adipose tissue before birth which is crucial for energy storage and thermogenesis in the neonatal period, and for long term metabolic health. The design uses the thyroid deficiency sheep fetus examined at two different gestational ages.
ORGANISM(S): Ovis aries 
2020-03-31 | E-MTAB-8396 | biostudies-arrayexpress
ProteomicsChemoproteomics of microbiota-derived indole metabolites in mammalian cells
The microbiota generates diverse metabolites to modulate host physiology and disease, but their protein targets and mechanisms of action have not been fully elucidated. To address this challenge, we focused on microbiota-derived indole metabolites and develop photoaffinity chemical probes for proteo...
ORGANISM(S): Homo sapiens (Human) 
2023-05-31 | PXD040163 | Pride
Bacterial metabolites Mammalian cells Chemical proteomics Photoaffinity probes 
TranscriptomicsMenstrual flow as a non-invasive source of endometrial organoids
Organoid cultures derived from menstrual flow faithfully replicate secretory phase endometrial glands and provide a novel, non-invasive technique for the clinical assessment of endometrial function. Paired organoid cultures derived from scratch biopsies and ensuing menstrual flow share the same tran...
ORGANISM(S): Homo sapiens 
2021-04-13 | E-MTAB-9284 | biostudies-arrayexpress
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