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UnknownConstruction and validation of a regulatory T cells-based classification of renal cell carcinoma: an integrated bioinformatic analysis and clinical cohort study.

Purpose

Renal cell carcinoma (RCC), exhibiting remarkable heterogeneity, can be highly infiltrated by regulatory T cells (Tregs). However, the relationship between Treg and the heterogeneity of RCC remains to be explored.

Methods

We acquired single-cell RNA-seq profiles and 537 bulk R...
S-EPMC12119669 | biostudies-literature
UnknownConstruction and validation of renal cell carcinoma tumor cell differentiation-related prognostic classification (RCC-TCDC): an integrated bioinformatic analysis and clinical study.

Background

Renal cell carcinoma (RCC) is a heterogeneous malignancy with diverse gene expression patterns, molecular landscapes, and differentiation characteristics of tumor cells. It is imperative to develop molecular RCC classification based on tumor cell differentiation for precise risk s...
S-EPMC12010653 | biostudies-literature
UnknownUnveiling the unique role of TSPAN7 across tumors: a pan-cancer study incorporating retrospective clinical research and bioinformatic analysis.

Background

TSPAN7 is an important factor in tumor progression. However, the precise function of TSPAN7 and its role in pan-cancer are not clear.

Methods

Based on Xinhua cohort incorporating 370 patients with kidney neoplasm, we conducted differential expression analysis by immunohisto...
S-EPMC11340126 | biostudies-literature
UnknownMachine learning-based derivation and validation of three immune phenotypes for risk stratification and prognosis in community-acquired pneumonia: a retrospective cohort study.

Background

The clinical presentation of Community-acquired pneumonia (CAP) in hospitalized patients exhibits heterogeneity. Inflammation and immune responses play significant roles in CAP development. However, research on immunophenotypes in CAP patients is limited, with few machine learning...
S-EPMC11303239 | biostudies-literature
UnknownComparative population genomics analysis uncovers genomic footprints and genes influencing body weight trait in Chinese indigenous chicken.
Body weight of chicken is a typical quantitative trait, which shows phenotypic variations due to selective breeding. Despite some QTL loci have been obtained, the body weight of native chicken breeds in different geographic regions varies greatly, its genetic basis remains unresolved questions. To a...
S-EPMC10511812 | biostudies-literature
UnknownClinical and Genetic Features of Familial Exudative Vitreoretinopathy With Only-Unilateral Abnormalities in a Chinese Cohort.

Importance

Familial exudative vitreoretinopathy (FEVR) with only-unilateral abnormalities may masquerade as other vitreoretinal disorders. Clinicians should be vigilant of patients with unilateral FEVR, recognizing that the relatively normal vision of the fellow eye could compromise a patien...
S-EPMC6555475 | biostudies-literature
UnknownAfatinib in combination with GEMOX chemotherapy as the adjuvant treatment in patients with ErbB pathway mutated, resectable gallbladder cancer: study protocol for a ctDNA-based, multicentre, open-label, randomised, controlled, phase II trial.

Introduction

Gallbladder cancer (GBC) is an aggressive type of digestive system cancer with a dismal outcome. Given the lack of effective treatment options, the disease rapidly reoccurs and 5-year survival rate is <5%. Our team previously found that a significant percentage of GBC tissues ha...
S-EPMC9980349 | biostudies-literature
UnknownEpidemiology of Atrial Fibrillation and Related Myocardial Ischemia or Arrhythmia Events in Chinese Community Population in 2019.

Background

Atrial fibrillation (AF) is the most common arrhythmia, and the incidence increases rapidly all over the world. The global prevalence of AF (age-adjusted) is 0.60% for men and 0.37% for women and the prevalence of AF in China is 0.65%. It is expected that the number of patients wi...
S-EPMC9013769 | biostudies-literature
UnknownAI-driven breath biopsy from a case-control study assists in the early detection of paediatric brain tumours.

Background

Paediatric brain tumours (PBT) are among the deadliest childhood cancers, with delayed diagnosis often limiting early intervention. This study explores exhaled volatile metabolites as potential biomarkers for PBT, employing AI to identify diagnostic markers and develop a predictiv...
S-EPMC12790591 | biostudies-literature
UnknownKnowledge and behavior regarding pesticide use: a survey among caregivers of children aged 1-6 years from rural China.
Little is known about pesticide exposure risks for children in rural areas in China, many of whom have been left behind by migrant workers. To survey caregivers of children in rural China and assess their pesticide use and disposal methods, the measures were used to protect the children and their pe...
S-EPMC6658672 | biostudies-literature
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